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    URB1 Urb1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853855, updated on 17-May-2024

    Summary

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    Gene symbol
    URB1
    Gene description
    Urb1p
    Primary source
    FungiDB:YKL014C
    Locus tag
    YKL014C
    See related
    SGD:S000001497; AllianceGenome:SGD:S000001497; VEuPathDB:YKL014C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NPA1
    Summary
    Enables mRNA binding activity. Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Orthologous to human URB1 (URB1 ribosome biogenesis homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See URB1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (411619..416913, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit d Neighboring gene Put3p Neighboring gene Arc19p Neighboring gene Prp40p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae. Rosado IV, et al. RNA, 2004 Jul. PMID 15208443, Free PMC Article
    2. Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis. Rosado IV, et al. Mol Cell Biol, 2007 Feb. PMID 17145778, Free PMC Article
    3. Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast. Jaafar M, et al. Nat Commun, 2021 Oct 22. PMID 34686656, Free PMC Article
    4. The Npa1p complex chaperones the assembly of the earliest eukaryotic large ribosomal subunit precursor. Joret C, et al. PLoS Genet, 2018 Aug. PMID 30169518, Free PMC Article
    5. The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis. Chen YL, et al. Nucleic Acids Res, 2014 Jun. PMID 24823796, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rbp95 binds to 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation.
      Title: Rbp95 binds to 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation.
    2. These results support the idea that Npa2p, Dbp6p, Npa1p, Nop8p, and Rsa3p work in concert during the early steps of 60S subunit biogenesis.
      Title: Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Urb1p
    NP_012911.3
    • Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      411619..416913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179580.3 → NP_012911.3  TPA: Urb1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012911.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXS2, P34241, P34242
      UniProtKB/TrEMBL
      A0A8H4BZ56, A6ZZV1, N1P0D2
      Conserved Domains (2) summary
      pfam11707
      Location:61 → 390
      Npa1; Ribosome 60S biogenesis N-terminal
      pfam16201
      Location:1460 → 1684
      NopRA1; Nucleolar pre-ribosomal-associated protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34241.2

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