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    RSR1 Ras family GTPase RSR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853056, updated on 17-May-2024

    Summary

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    Gene symbol
    RSR1
    Gene description
    Ras family GTPase RSR1
    Primary source
    FungiDB:YGR152C
    Locus tag
    YGR152C
    See related
    SGD:S000003384; AllianceGenome:SGD:S000003384; VEuPathDB:YGR152C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BUD1
    Summary
    Enables GTPase activity. Involved in several processes, including cellular bud site selection; positive regulation of Rho guanyl-nucleotide exchange factor activity; and positive regulation of Rho protein signal transduction. Located in several cellular components, including cell division site; cellular bud neck; and vacuolar membrane. Part of incipient cellular bud site. Orthologous to several human genes including RAP1A (RAP1A, member of RAS oncogene family) and RAP1B (RAP1B, member of RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RSR1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (794674..795492, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ccm1p Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein Neighboring gene omega-class glutathione transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery. Wang X, et al. J Cell Biol, 2022 Dec 5. PMID 36156058, Free PMC Article
    2. Localization of the Rsr1/Bud1 GTPase involved in selection of a proper growth site in yeast. Park HO, et al. J Biol Chem, 2002 Jul 26. PMID 12058023
    3. Rsr1 and Rap1 GTPases are activated by the same GTPase-activating protein and require threonine 65 for their activation. Holden JL, et al. J Biol Chem, 1991 Sep 15. PMID 1910037
    4. Exploratory polarization facilitates mating partner selection in Saccharomyces cerevisiae. Clark-Cotton MR, et al. Mol Biol Cell, 2021 May 1. PMID 33689470, Free PMC Article
    5. Tracking shallow chemical gradients by actin-driven wandering of the polarization site. Dyer JM, et al. Curr Biol, 2013 Jan 7. PMID 23200992, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery.
      Title: Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of protein location in cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic G1 phase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in incipient cellular bud site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of polarized growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ras family GTPase RSR1
    NP_011668.3
    • Ras-type GTPase; required for bud site selection during both axial and bipolar budding, for morphological changes in response to mating pheromone, and for efficient cell fusion; recruits Cdc24p to the incipient bud site, activating its guanyl-nucleotide exchange factor activity and the Rho-like GTPase, Cdc42p; localizes to the plasma membrane, the incipient bud site, polarized growth sites, the cell division site and the vacuole membrane; Ras superfamily member similar to mammalian Rap GTPases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      794674..795492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181281.3 → NP_011668.3  TPA: Ras family GTPase RSR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011668.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUT2, P13856
      UniProtKB/TrEMBL
      A0A6A5PYW2, C8Z946, G2WEN2, N1P2D7
      Conserved Domains (1) summary
      cd04177
      Location:3 → 166
      RSR1; RSR1/Bud1p family GTPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13856.1

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