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    RRP1 Rrp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851660, updated on 17-May-2024

    Summary

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    Gene symbol
    RRP1
    Gene description
    Rrp1p
    Primary source
    FungiDB:YDR087C
    Locus tag
    YDR087C
    See related
    SGD:S000002494; AllianceGenome:SGD:S000002494; VEuPathDB:YDR087C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in rRNA processing. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human RRP1 (ribosomal RNA processing 1) and RRP1B (ribosomal RNA processing 1B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RRP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (617470..618306, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Afr1p Neighboring gene translocon subunit SSS1 Neighboring gene mRNA splicing protein SLU7 Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RRP1, a Saccharomyces cerevisiae gene affecting rRNA processing and production of mature ribosomal subunits. Fabian GR, et al. J Bacteriol, 1987 Apr. PMID 3549696, Free PMC Article
    2. SRD1, a S. cerevisiae gene affecting pre-rRNA processing contains a C2/C2 zinc finger motif. Hess SM, et al. Nucleic Acids Res, 1994 Apr 11. PMID 8165142, Free PMC Article
    3. srd1, a Saccharomyces cerevisiae suppressor of the temperature-sensitive pre-rRNA processing defect of rrp1-1. Fabian GR, et al. Genetics, 1990 Mar. PMID 2179050, Free PMC Article
    4. Rrb1p, a yeast nuclear WD-repeat protein involved in the regulation of ribosome biosynthesis. Iouk TL, et al. Mol Cell Biol, 2001 Feb. PMID 11158312, Free PMC Article
    5. Competition between the Rex1 exonuclease and the La protein affects both Trf4p-mediated RNA quality control and pre-tRNA maturation. Copela LA, et al. RNA, 2008 Jun. PMID 18456844, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of preribosome, small subunit precursor IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rrp1p
    NP_010372.3
    • Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      617470..618306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180395.3 → NP_010372.3  TPA: Rrp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010372.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS74, P35178
      UniProtKB/TrEMBL
      A0A8H8UN04, A6ZY53, B3LGI4, B5VFY3, C7GVP9, C8Z505, N1P6A0
      Conserved Domains (1) summary
      pfam05997
      Location:4 → 244
      Nop52; Nucleolar protein,Nop52
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    5Z3G_X.1
    6EM1_4.1
    6EM3_4.1
    6EM4_4.1
    6EM5_4.1
    7OHS_4.1
    7OHW_4.1
    7OHX_4.1
    P35178.2

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