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    Lacc1 laccase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 210808, updated on 12-May-2024

    Summary

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    Official Symbol
    Lacc1provided by MGI
    Official Full Name
    laccase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2445077
    See related
    Ensembl:ENSMUSG00000044350 AllianceGenome:MGI:2445077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030625A04Rik
    Summary
    Predicted to enable adenosine deaminase activity; copper ion binding activity; and pentosyltransferase activity. Involved in regulation of inflammatory response and regulation of purine nucleotide metabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis. Orthologous to human LACC1 (laccase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.9), liver E18 (RPKM 5.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lacc1 in Genome Data Viewer
    Location:
    14 D3; 14 40.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (77261640..77274344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77021739..77036929, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37199 Neighboring gene STARR-seq mESC enhancer starr_37200 Neighboring gene predicted gene, 30365 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77411648-77411949 Neighboring gene STARR-seq mESC enhancer starr_37202 Neighboring gene STARR-seq mESC enhancer starr_37203 Neighboring gene STARR-positive B cell enhancer ABC_E5459 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_37204 Neighboring gene coiled-coil domain containing 122 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77541449-77541750 Neighboring gene STARR-seq mESC enhancer starr_37206 Neighboring gene ecto-NOX disulfide-thiol exchanger 1 Neighboring gene STARR-seq mESC enhancer starr_37207 Neighboring gene STARR-seq mESC enhancer starr_37208 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene predicted gene, 41217

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A purine metabolic checkpoint that prevents autoimmunity and autoinflammation. Saveljeva S, et al. Cell Metab, 2022 Jan 4. PMID 34986329, Free PMC Article
    2. Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation. Kang JW, et al. Gastroenterology, 2020 Sep. PMID 32693188, Free PMC Article
    3. LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation. Skon-Hegg C, et al. J Immunol, 2019 Jan 1. PMID 30510070, Free PMC Article
    4. LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. Wei Z, et al. Nature, 2022 Sep. PMID 35978195, Free PMC Article
    5. C13orf31 (FAMIN) is a central regulator of immunometabolic function. Cader MZ, et al. Nat Immunol, 2016 Sep. PMID 27478939, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease.
      Title: LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease.
    2. LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
      Title: LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
    3. Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation.
      Title: Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation.
    4. this study shows that LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation
      Title: LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.
    5. this study shows that Lacc1 is a central regulator of the metabolic function and bioenergetic state of macrophages that is under evolutionary selection and determines the risk of inflammatory and infectious disease
      Title: C13orf31 (FAMIN) is a central regulator of immunometabolic function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2'-deoxyadenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-methyl-5-thioadenosine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanosine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine-nucleoside phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of purine nucleotide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    purine nucleoside phosphorylase LACC1
    Names
    S-methyl-5'-thioadenosine phosphorylase LACC1
    adenosine deaminase LACC1
    fatty acid metabolism-immunity nexus
    guanosine phosphorylase LACC1
    laccase (multicopper oxidoreductase) domain containing 1
    laccase domain-containing protein 1
    NP_766076.1
    XP_030103569.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172488.2 → NP_766076.1  purine nucleoside phosphorylase LACC1

      See identical proteins and their annotated locations for NP_766076.1

      Status: PROVISIONAL

      Source sequence(s)
      AK033565
      Consensus CDS
      CCDS27287.1
      UniProtKB/Swiss-Prot
      Q14AQ3, Q3U600, Q8BZT9
      Related
      ENSMUSP00000059173.9, ENSMUST00000062789.15
      Conserved Domains (1) summary
      pfam02578
      Location:218 → 426
      Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      77261640..77274344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247709.2 → XP_030103569.1  purine nucleoside phosphorylase LACC1 isoform X1

      Conserved Domains (1) summary
      pfam02578
      Location:5 → 170
      Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

    RNA

    1. XR_003950831.2 RNA Sequence

    2. XR_383153.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZT9.1 GenPept UniProtKB/Swiss-Prot:Q8BZT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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