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    Tmem208 transmembrane protein 208 [ Mus musculus (house mouse) ]

    Gene ID: 66320, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem208provided by MGI
    Official Full Name
    transmembrane protein 208provided by MGI
    Primary source
    MGI:MGI:1913570
    See related
    Ensembl:ENSMUSG00000014856 AllianceGenome:MGI:1913570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hspc171; 1700006C06Rik; 2610030K20Rik
    Summary
    Predicted to be involved in vacuolar protein processing. Predicted to act upstream of or within autophagy. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human TMEM208 (transmembrane protein 208). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 31.1), large intestine adult (RPKM 28.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem208 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106052980..106062117)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105326341..105335485)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328 Neighboring gene F-box and leucine-rich repeat protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene formin homology 2 domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene predicted gene, 46049 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability.
      Title: Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC25457

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 208

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378965.1 → NP_001365894.1  transmembrane protein 208 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC124584
      Conserved Domains (1) summary
      pfam05620
      Location:8 → 162
      DUF788; Protein of unknown function (DUF788)

    2. NM_001378966.1 → NP_001365895.1  transmembrane protein 208 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124584
      Related
      ENSMUSP00000096052.3, ENSMUST00000098453.9
      Conserved Domains (1) summary
      pfam05620
      Location:8 → 100
      DUF788; Protein of unknown function (DUF788)

    3. NM_001378967.1 → NP_001365896.1  transmembrane protein 208 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124584
      UniProtKB/TrEMBL
      D3Z7S5
      Related
      ENSMUSP00000104997.2, ENSMUST00000109372.3
      Conserved Domains (1) summary
      pfam05620
      Location:8 → 100
      DUF788; Protein of unknown function (DUF788)

    4. NM_001378968.1 → NP_001365897.1  transmembrane protein 208 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC124584
      UniProtKB/TrEMBL
      S4R1H6
      Related
      ENSMUSP00000138470.2, ENSMUST00000153146.9
      Conserved Domains (1) summary
      pfam05620
      Location:8 → 100
      DUF788; Protein of unknown function (DUF788)

    5. NM_025486.3 → NP_079762.1  transmembrane protein 208 isoform 3

      See identical proteins and their annotated locations for NP_079762.1

      Status: VALIDATED

      Source sequence(s)
      AC124584
      Consensus CDS
      CCDS22599.1
      UniProtKB/Swiss-Prot
      Q3V2H5, Q8R1F8, Q9CR96
      Related
      ENSMUSP00000015000.5, ENSMUST00000015000.12
      Conserved Domains (1) summary
      pfam05620
      Location:8 → 156
      DUF788; Protein of unknown function (DUF788)

    RNA

    1. NR_166208.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124584

    2. NR_166209.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124584

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106052980..106062117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531277.5 → XP_006531340.1  transmembrane protein 208 isoform X1

      See identical proteins and their annotated locations for XP_006531340.1

      UniProtKB/TrEMBL
      S4R1H6
      Conserved Domains (1) summary
      pfam05620
      Location:8 → 100
      DUF788; Protein of unknown function (DUF788)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR96.1 GenPept UniProtKB/Swiss-Prot:Q9CR96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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