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    Sae1 SUMO1 activating enzyme subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 56459, updated on 9-May-2024

    Summary

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    Official Symbol
    Sae1provided by MGI
    Official Full Name
    SUMO1 activating enzyme subunit 1provided by MGI
    Primary source
    MGI:MGI:1929264
    See related
    Ensembl:ENSMUSG00000052833 AllianceGenome:MGI:1929264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AOS1; Sua1; Uble1a; HSPC140; D7Ertd177e; 2400010M20Rik; 2610044L12Rik
    Summary
    Predicted to enable several functions, including ATP-dependent protein binding activity; SUMO activating enzyme activity; and protein C-terminus binding activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Predicted to be located in nucleoplasm. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in genitourinary system. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 52.3), placenta adult (RPKM 35.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sae1 in Genome Data Viewer
    Location:
    7 A2; 7 8.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16054161..16121821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16320236..16387896, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3699 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:16880265-16880374 Neighboring gene STARR-positive B cell enhancer ABC_E6516 Neighboring gene STARR-seq mESC enhancer starr_18129 Neighboring gene STARR-seq mESC enhancer starr_18130 Neighboring gene BCL2 binding component 3 Neighboring gene predicted gene, 57781 Neighboring gene STARR-seq mESC enhancer starr_18132 Neighboring gene STARR-positive B cell enhancer ABC_E4898 Neighboring gene STARR-seq mESC enhancer starr_18133 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E347 Neighboring gene transmembrane protein 160

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression and regulation of the mammalian SUMO-1 E1 enzyme. Azuma Y, et al. FASEB J, 2001 Aug. PMID 11481243
    2. Biotin-ubiquitin tagging of mammalian proteins in Escherichia coli. Wang T, et al. Protein Expr Purif, 2003 Jul. PMID 12821332
    3. Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Su HL, et al. Gene, 2002 Aug 21. PMID 12383504
    4. Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Ban R, et al. Genes Cells, 2011 Jun. PMID 21554500
    5. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. Aweida D, et al. EMBO Rep, 2022 Dec 6. PMID 36278411, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to SUMO activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SUMO activating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-activating enzyme subunit 1
    Names
    SUMO-1 activating enzyme subunit 1
    ubiquitin-like (sentrin) activating enzyme E1A
    ubiquitin-like 1 (sentrin) activating enzyme E1A
    ubiquitin-like 1 (sentrin) activating enzyme subunit 1
    ubiquitin-like 1-activating enzyme E1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285891.1 → NP_001272820.1  SUMO-activating enzyme subunit 1 isoform a

      See identical proteins and their annotated locations for NP_001272820.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC164880, AK162789, BB838763, BC068164
      Consensus CDS
      CCDS20848.1
      UniProtKB/Swiss-Prot
      Q3TRG9, Q3TWJ0, Q9CSW9, Q9R1T2
      Related
      ENSMUSP00000147409.2, ENSMUST00000210999.2
      Conserved Domains (2) summary
      cd01492
      Location:20 → 345
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:23 → 338
      ThiF; ThiF family

    2. NM_001285892.1 → NP_001272821.1  SUMO-activating enzyme subunit 1 isoform b

      See identical proteins and their annotated locations for NP_001272821.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC164880, AK011772, AK162789, BB838763
      Consensus CDS
      CCDS85221.1
      UniProtKB/Swiss-Prot
      Q9R1T2
      Related
      ENSMUSP00000147771.2, ENSMUST00000211741.2
      Conserved Domains (2) summary
      cd01492
      Location:20 → 173
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:23 → 171
      ThiF; ThiF family

    3. NM_019748.3 → NP_062722.1  SUMO-activating enzyme subunit 1 isoform a

      See identical proteins and their annotated locations for NP_062722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC164880, BB838763, BC068164
      Consensus CDS
      CCDS20848.1
      UniProtKB/Swiss-Prot
      Q3TRG9, Q3TWJ0, Q9CSW9, Q9R1T2
      Related
      ENSMUSP00000092409.4, ENSMUST00000094815.5
      Conserved Domains (2) summary
      cd01492
      Location:20 → 345
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:23 → 338
      ThiF; ThiF family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      16054161..16121821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250653.2 → XP_011248955.1  SUMO-activating enzyme subunit 1 isoform X1

      Conserved Domains (1) summary
      cd01492
      Location:20 → 173
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1T2.1 GenPept UniProtKB/Swiss-Prot:Q9R1T2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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