Ogfr opioid growth factor receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ogfrprovided by MGI
Official Full Name: opioid growth factor receptorprovided by MGI
Primary source: MGI:MGI:1919325
See related: Ensembl:ENSMUSG00000049401 AllianceGenome:MGI:1919325
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010013E17Rik
Summary: Predicted to enable G protein-coupled opioid receptor activity. Predicted to act upstream of or within regulation of growth. Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in genitourinary system and metanephros. Orthologous to human OGFR (opioid growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 34.2), CNS E14 (RPKM 28.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.13 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180231200..180237630)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180589407..180595837)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain.
Title: Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain.
These data demonstrate for the first time that stable genetic amplification of OGFr downregulates homeostatic cell proliferation, as well as pathophysiological processes with respect to wound repair.
Title: Targeted overexpression of OGFr in epithelium of transgenic mice suppresses cell proliferation and impairs full-thickness wound closure.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables opioid growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: opioid growth factor receptor

Names: zeta-type opioid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031373.3 → NP_113550.3 opioid growth factor receptor

See identical proteins and their annotated locations for NP_113550.3

Status: VALIDATED

Source sequence(s)

AF303894, CJ144579, CO040942

Consensus CDS

CCDS17179.1

UniProtKB/Swiss-Prot

A2ACT6, Q99L33, Q99PG2

UniProtKB/TrEMBL

Q80UU6

Related

ENSMUSP00000029087.4, ENSMUST00000029087.4

Conserved Domains (3) summary

PHA03169
Location:284 → 548

PHA03169; hypothetical protein; Provisional

pfam04664
Location:76 → 283

OGFr_N; Opioid growth factor receptor (OGFr) conserved region

pfam15231
Location:472 → 620

VCX_VCY; Variable charge X/Y family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

180231200..180237630

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319269.3 → XP_017174758.1 opioid growth factor receptor isoform X1

UniProtKB/TrEMBL

Q80UU6

Conserved Domains (3) summary

PTZ00449
Location:414 → 612

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03169
Location:263 → 527

PHA03169; hypothetical protein; Provisional

pfam04664
Location:55 → 262

OGFr_N; Opioid growth factor receptor (OGFr) conserved region
XM_036162586.1 → XP_036018479.1 opioid growth factor receptor isoform X2

UniProtKB/TrEMBL

Q80UU6

Conserved Domains (2) summary

PTZ00449
Location:349 → 547

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

pfam04664
Location:38 → 197

OGFr_N; Opioid growth factor receptor (OGFr) conserved region