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    Timp1 tissue inhibitor of metalloproteinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 21857, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Timp1provided by MGI
    Official Full Name
    tissue inhibitor of metalloproteinase 1provided by MGI
    Primary source
    MGI:MGI:98752
    See related
    Ensembl:ENSMUSG00000001131 AllianceGenome:MGI:98752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EPA; Clgi; Timp; TIMP-1; TPA-S1
    Summary
    Predicted to enable several functions, including cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Located in basement membrane. Is expressed in several structures, including early conceptus; hindlimb cartilage condensation; jaw; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 113.3), adrenal adult (RPKM 13.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A1.3; X 16.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20736524..20740972)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20870166..20874737)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Araf proto-oncogene, serine/threonine kinase Neighboring gene STARR-positive B cell enhancer ABC_E1532 Neighboring gene ribonuclease UK114 pseudogene Neighboring gene microRNA 5617 Neighboring gene synapsin I Neighboring gene STARR-seq mESC enhancer starr_46887 Neighboring gene STARR-seq mESC enhancer starr_46888 Neighboring gene complement factor properdin Neighboring gene ELK1, member of ETS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tissue inhibitor of metalloproteinase 1 suppresses growth and differentiation of osteoblasts and differentiation of osteoclasts by targeting the AKT pathway. Xi Y, et al. Exp Cell Res, 2020 Apr 15. PMID 32113948
    2. AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice. Remes A, et al. J Heart Lung Transplant, 2020 Apr. PMID 32035727
    3. TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms. Knight BE, et al. Front Mol Neurosci, 2019. PMID 31616247, Free PMC Article
    4. TIMP-1 Promotes the Immune Response in Influenza-Induced Acute Lung Injury. Allen JR, et al. Lung, 2018 Dec. PMID 30167842, Free PMC Article
    5. Adeno-Associated Virus-Mediated Gene Transfer of Tissue Inhibitor of Metalloproteinases-1 Impairs Neutrophil Extracellular Trap Formation and Ameliorates Hepatic Ischemia and Reperfusion Injury. Duarte S, et al. Am J Pathol, 2018 Aug. PMID 29870740, Free PMC Article

    See all (277) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection.
      Title: Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection.
    2. RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-kappaB signaling pathway.
      Title: RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-κB signaling pathway.
    3. The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
      Title: The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
    4. CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.
      Title: CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.
    5. siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
      Title: siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
    6. Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
      Title: Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
    7. Histological characteristics of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in asthmatic murine model during A(H1N1)pdm09 infection.
      Title: Histological characteristics of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in asthmatic murine model during A(H1N1)pdm09 infection.
    8. Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.
      Title: Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.
    9. The effects of exercise training on cardiac matrix metalloproteinases activity and cardiac function in mice with diabetic cardiomyopathy.
      Title: The effects of exercise training on cardiac matrix metalloproteinases activity and cardiac function in mice with diabetic cardiomyopathy.
    10. TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer.
      Title: TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (119)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7143

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to UV-A ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metalloproteinase inhibitor 1
    Names
    TPA-induced protein
    collagenase inhibitor 16C8 fibroblast
    erythroid-potentiating activity
    tissue inhibitor of metalloproteinases 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044384.2 → NP_001037849.1  metalloproteinase inhibitor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001037849.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL671885
      Consensus CDS
      CCDS30046.1
      UniProtKB/Swiss-Prot
      P12032, P20064, Q61720
      Related
      ENSMUSP00000009530.5, ENSMUST00000009530.5
      Conserved Domains (1) summary
      smart00206
      Location:25 → 199
      NTR; Tissue inhibitor of metalloproteinase family

    2. NM_001294280.3 → NP_001281209.1  metalloproteinase inhibitor 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
      Source sequence(s)
      AL671885
      Conserved Domains (1) summary
      cl02512
      Location:1 → 131
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    3. NM_001426018.1 → NP_001412947.1  metalloproteinase inhibitor 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL671885

    4. NM_001426019.1 → NP_001412948.1  metalloproteinase inhibitor 1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL671885

    5. NM_001426020.1 → NP_001412949.1  metalloproteinase inhibitor 1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL671885

    6. NM_011593.3 → NP_035723.2  metalloproteinase inhibitor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_035723.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL671885
      Consensus CDS
      CCDS30046.1
      UniProtKB/Swiss-Prot
      P12032, P20064, Q61720
      Related
      ENSMUSP00000110999.4, ENSMUST00000115342.10
      Conserved Domains (1) summary
      smart00206
      Location:25 → 199
      NTR; Tissue inhibitor of metalloproteinase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      20736524..20740972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12032.2 GenPept UniProtKB/Swiss-Prot:P12032

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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