Asrgl1 asparaginase and isoaspartyl peptidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asrgl1provided by RGD
Official Full Name: asparaginase and isoaspartyl peptidase 1provided by RGD
Primary source: RGD:708526
See related: Ensembl:ENSRNOG00000020202 AllianceGenome:RGD:708526
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gliap; Hiob2
Summary: Enables asparaginase activity. Acts upstream of or within asparagine catabolic process via L-aspartate. Located in cytoplasm. Orthologous to human ASRGL1 (asparaginase and isoaspartyl peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 1001.4), Kidney (RPKM 351.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215436180..215456188, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (206006103..206027115, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (225309737..225329743, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel asparaginase-like protein (ALP) of spermatozoa was cloned from rat and human testis cDNA libraries on the basis of reactivity with antibodies produced after vasectomy
Title: A novel asparaginase-like protein is a sperm autoantigen in rats.
Gliap is abundant in liver and testis and in brain Gliap is exclusively expressed in astrocytes and present in structures resembling glial endfeet. This suggests Gliap is involved in astroglial production of the neuroactive amino acid L-aspartate
Title: Gliap--a novel untypical L-asparaginase localized to rat brain astrocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE120471 (e-PCR)
- UniSTS:247340

BI280488 (e-PCR)
- UniSTS:249040

RH131748 (e-PCR)
- UniSTS:215031

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity	ISO Inferred from Sequence Orthology more info
enables asparaginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables asparaginase activity	IDA Inferred from Direct Assay more info	PubMed
enables asparaginase activity	IEA Inferred from Electronic Annotation more info
enables asparaginase activity	ISO Inferred from Sequence Orthology more info
enables beta-aspartyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-aspartyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables beta-aspartyl-peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in asparagine catabolic process via L-aspartate	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within asparagine catabolic process via L-aspartate	IDA Inferred from Direct Assay more info	PubMed
involved_in asparagine catabolic process via L-aspartate	IDA Inferred from Direct Assay more info	PubMed
involved_in asparagine catabolic process via L-aspartate	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: isoaspartyl peptidase/L-asparaginase

Names: L-asparaginase; L-asparagine amidohydrolase; asparaginase like 1; asparaginase-like protein 1; asparaginase-like sperm autoantigen; beta-aspartyl-peptidase; glial asparaginase; isoaspartyl dipeptidase

NP_659557.1

EC 3.4.19.5

EC 3.5.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145089.4 → NP_659557.1 isoaspartyl peptidase/L-asparaginase

See identical proteins and their annotated locations for NP_659557.1

Status: PROVISIONAL

Source sequence(s)

AF329099

UniProtKB/Swiss-Prot

Q8CG44, Q8VI04

UniProtKB/TrEMBL

A0A8L2QFS3, A6HZZ2

Related

ENSRNOP00000027459.2, ENSRNOT00000027459.5

Conserved Domains (2) summary

PRK10226
Location:27 → 306

PRK10226; isoaspartyl peptidase; Provisional

cd04702
Location:25 → 314

ASRGL1_like; Metazoan L-Asparaginase type 2