Cnmd chondromodulin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnmdprovided by RGD
Official Full Name: chondromodulinprovided by RGD
Primary source: RGD:620176
See related: Ensembl:ENSRNOG00000012821 AllianceGenome:RGD:620176
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Chm-1; Lect1
Summary: Predicted to be involved in several processes, including endothelial cell morphogenesis; negative regulation of endothelial cell proliferation; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in endomembrane system and extracellular region. Predicted to be integral component of membrane. Orthologous to human CNMD (chondromodulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 12.6), Lung (RPKM 5.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (61450617..61475382, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (55041548..55066297, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (61923291..61947840, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate novel information about the molecular mechanism by which ChM-I induce MSCs to differentiate into chondrocytes.
Title: Proteomic analysis of chondromodulin-I-induced differentiation of mesenchymal stem cells into chondrocytes.
intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage
Title: The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.
Data show that chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages.
Title: Identification of differentially expressed genes in mandibular condylar and tibial growth cartilages using laser microdissection and fluorescent differential display: chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages.
Chm-1 expression was studied in articular cartilage and compared with that in the growth plate.
Title: Chondromodulin-I expression in rat articular cartilage.
In experimental uremia, expansion of growth cartilage does not result from increased or persistent expression of ChM-I or from reduced VEGF expression at the cartilage-metaphyseal bone interphase.
Title: Chondromodulin-I expression in the growth plate of young uremic rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leukocyte cell-derived chemotaxin 1

Names: chM-I; chondromodulin-1; chondromodulin-I; leukocyte cell derived chemotaxin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030854.1 → NP_110481.1 leukocyte cell-derived chemotaxin 1

See identical proteins and their annotated locations for NP_110481.1

Status: PROVISIONAL

Source sequence(s)

AF051425

UniProtKB/Swiss-Prot

O70367

UniProtKB/TrEMBL

A0JPL7

Related

ENSRNOP00000017400.3, ENSRNOT00000017400.4

Conserved Domains (1) summary

smart01039
Location:105 → 201

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

61450617..61475382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252346.4 → XP_006252408.1 leukocyte cell-derived chemotaxin 1 isoform X1

UniProtKB/TrEMBL

A0JPL7

Conserved Domains (1) summary

smart01039
Location:105 → 201

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer