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    Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 59126, updated on 12-May-2024

    Summary

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    Official Symbol
    Nek6provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 6provided by MGI
    Primary source
    MGI:MGI:1891638
    See related
    Ensembl:ENSMUSG00000026749 AllianceGenome:MGI:1891638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300007C09Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; enzyme binding activity; and kinesin binding activity. Predicted to be involved in chromosome segregation; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within apoptotic process; cell division; and phosphorylation. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NEK6 (NIMA related kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 28.6), small intestine adult (RPKM 28.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 24.41 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38314052..38477502)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (38483863..38587490)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 27197 Neighboring gene STARR-seq mESC enhancer starr_04322 Neighboring gene LIM homeobox protein 2 Neighboring gene predicted gene 13584 Neighboring gene STARR-seq mESC enhancer starr_04324 Neighboring gene predicted gene, 39799 Neighboring gene predicted gene, 25081 Neighboring gene STARR-positive B cell enhancer ABC_E4444 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04330 Neighboring gene predicted gene, 35808 Neighboring gene STARR-seq mESC enhancer starr_04333 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38471578-38471879 Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 Neighboring gene STARR-positive B cell enhancer ABC_E4445 Neighboring gene STARR-seq mESC enhancer starr_04335 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:38499471-38499654 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04336 Neighboring gene adhesion G protein-coupled receptor D2, pseudogene Neighboring gene predicted gene, 36744

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6. Jeltema D, et al. J Immunol, 2022 Apr 15. PMID 35354613, Free PMC Article
    2. Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy. Bian Z, et al. PLoS One, 2014. PMID 24763737, Free PMC Article
    3. Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. Jeon YJ, et al. J Biol Chem, 2010 Sep 3. PMID 20595392, Free PMC Article
    4. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. Fu B, et al. mBio, 2020 Jun 2. PMID 32487755, Free PMC Article
    5. Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. Hashimoto Y, et al. Biochem Biophys Res Commun, 2002 May 3. PMID 12054534

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.
      Title: A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.
    2. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling.
      Title: MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling.
    3. NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
      Title: Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.
    4. During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
      Title: The related murine kinases, Nek6 and Nek7, display distinct patterns of expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek6
    Names
    NIMA-related expressed kinase 6
    never in mitosis A-related kinase 6
    nimA-related protein kinase 6
    NP_001153103.1
    NP_067619.1
    XP_006498272.1
    XP_006498273.1
    XP_030107782.1
    XP_030107783.1
    XP_030107784.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159631.1 → NP_001153103.1  serine/threonine-protein kinase Nek6

      See identical proteins and their annotated locations for NP_001153103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK086700, BY205493
      Consensus CDS
      CCDS16009.1
      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Related
      ENSMUSP00000108516.2, ENSMUST00000112895.8
      Conserved Domains (1) summary
      cd08228
      Location:42 → 309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

    2. NM_021606.3 → NP_067619.1  serine/threonine-protein kinase Nek6

      See identical proteins and their annotated locations for NP_067619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF218847, AK086700
      Consensus CDS
      CCDS16009.1
      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Related
      ENSMUSP00000049723.4, ENSMUST00000054234.10
      Conserved Domains (1) summary
      cd08228
      Location:42 → 309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      38314052..38477502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251924.2 → XP_030107784.1  serine/threonine-protein kinase Nek6 isoform X2

      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Conserved Domains (1) summary
      cd08228
      Location:42 → 309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

    2. XM_030251922.2 → XP_030107782.1  serine/threonine-protein kinase Nek6 isoform X2

      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Conserved Domains (1) summary
      cd08228
      Location:42 → 309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

    3. XM_030251923.2 → XP_030107783.1  serine/threonine-protein kinase Nek6 isoform X2

      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Conserved Domains (1) summary
      cd08228
      Location:42 → 309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

    4. XM_006498210.5 → XP_006498273.1  serine/threonine-protein kinase Nek6 isoform X2

      See identical proteins and their annotated locations for XP_006498273.1

      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Conserved Domains (1) summary
      cd08228
      Location:42 → 309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

    5. XM_006498209.5 → XP_006498272.1  serine/threonine-protein kinase Nek6 isoform X1

      Conserved Domains (1) summary
      cd08228
      Location:87 → 354
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES70.1 GenPept UniProtKB/Swiss-Prot:Q9ES70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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