U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Glb1l2 galactosidase, beta 1-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 244757, updated on 12-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Glb1l2provided by MGI
    Official Full Name
    galactosidase, beta 1-like 2provided by MGI
    Primary source
    MGI:MGI:2388283
    See related
    Ensembl:ENSMUSG00000036395 AllianceGenome:MGI:2388283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable beta-galactosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in extracellular region. Predicted to be active in vacuole. Is expressed in foregut-midgut junction; molar; nose; urinary system; and vestibulo-cochlear ganglion. Orthologous to human GLB1L2 (galactosidase beta 1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 160.2), subcutaneous fat pad adult (RPKM 53.0) and 3 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    9 A4; 9 11.56 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26674338..26717769, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26763044..26806473, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30313 Neighboring gene STARR-seq mESC enhancer starr_23611 Neighboring gene STARR-seq mESC enhancer starr_23613 Neighboring gene beta-1,3-glucuronyltransferase 1 Neighboring gene galactosidase, beta 1 like 3 Neighboring gene STARR-seq mESC enhancer starr_23614 Neighboring gene predicted gene 1110

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC47419

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    beta-galactosidase-1-like protein 2
    NP_001297697.1
    NP_722498.1
    XP_006510360.1
    XP_006510361.1
    XP_006510362.1
    XP_006510363.1
    XP_006510365.1
    XP_006510366.1
    XP_036010874.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310768.1 → NP_001297697.1  beta-galactosidase-1-like protein 2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AI324066, AK033400, AK143057, BG061307, CF737161
      Consensus CDS
      CCDS80971.1
      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      UniProtKB/TrEMBL
      E0CYE1
      Related
      ENSMUSP00000066770.7, ENSMUST00000066560.13
      Conserved Domains (1) summary
      pfam01301
      Location:53 → 366
      Glyco_hydro_35; Glycosyl hydrolases family 35

    2. NM_153803.2 → NP_722498.1  beta-galactosidase-1-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_722498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC038479, BG061307
      Consensus CDS
      CCDS40566.1
      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      UniProtKB/TrEMBL
      A0A0R4J0L1
      Related
      ENSMUSP00000047128.8, ENSMUST00000040398.14
      Conserved Domains (1) summary
      pfam01301
      Location:69 → 382
      Glyco_hydro_35; Glycosyl hydrolases family 35

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      26674338..26717769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510297.5 → XP_006510360.1  beta-galactosidase-1-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:93 → 406
      Glyco_hydro_35; Glycosyl hydrolases family 35

    2. XM_006510302.4 → XP_006510365.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510365.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    3. XM_006510300.5 → XP_006510363.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510363.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    4. XM_006510303.3 → XP_006510366.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510366.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    5. XM_006510299.5 → XP_006510362.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510362.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    6. XM_006510298.4 → XP_006510361.1  beta-galactosidase-1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006510361.1

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Related
      ENSMUSP00000124415.2, ENSMUST00000162252.8
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35

    7. XM_036154981.1 → XP_036010874.1  beta-galactosidase-1-like protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3UPY5, Q8CFT1
      Conserved Domains (1) summary
      pfam01301
      Location:60 → 373
      Glyco_hydro_35; Glycosyl hydrolases family 35
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UPY5.1 GenPept UniProtKB/Swiss-Prot:Q3UPY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous