Idh1 isocitrate dehydrogenase (NADP(+)) 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Idh1provided by RGD
Official Full Name: isocitrate dehydrogenase (NADP(+)) 1provided by RGD
Primary source: RGD:2862
See related: Ensembl:ENSRNOG00000015020 AllianceGenome:RGD:2862
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IDPc
Summary: Enables NADP binding activity and isocitrate dehydrogenase (NADP+) activity. Involved in female gonad development; isocitrate metabolic process; and response to steroid hormone. Located in peroxisome. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1633.7), Kidney (RPKM 1182.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (74027887..74057442, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (66534146..66563703, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (71882108..71911645, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human-derived glioblastoma cell lines.
Title: In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human-derived glioblastoma cell lines.
The present research for the first time detected the expression and variation of IDH1 surrounding the hematoma, and all data proved the involvement of IDH1 in neuronal apoptosis following Intracranial hemorrhage.
Title: IDH1 Associated with Neuronal Apoptosis in Adult Rats Brain Following Intracerebral Hemorrhage.
IDHc as a component of the emerging pathways that negatively regulate glucose signaling for insulin secretion
Title: A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.
IDH1 mutations are closely associated with glioma progression and chemo-resistance.
Title: Glioma derived isocitrate dehydrogenase-2 mutations induced up-regulation of HIF-1α and β-catenin signaling: possible impact on glioma cell metastasis and chemo-resistance.
Activity of NADP-dependent isocitrate dehydrogenase increases and the catalytic characteristics of the enzyme isolated from the liver of rats are changed under conditions of apoptosis induction in comparison with these characteristics in health.
Title: Catalytic characteristics of NADP-isocitrate dehydrogenase from the liver of rats in health and after injection of TNF-α and melatonin treatment.
These results together indicate that upregulation of IDPc in response to hyperglycemia might play an essential role in preventing the progression of diabetic nephropathy.
Title: Upregulation of cytosolic NADP+-dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress.
modulation of ICDH is an age-dependent and a tissue-specific phenomenon
Title: Modulation of NADP(+)-dependent isocitrate dehydrogenase in aging.
a pyruvate cycling pathway involving ICDc plays an important role in control of glucose-stimulated insulin secretion
Title: A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.
cardiac mitochondrial NADP+-isocitrate dehydrogenase is a target for modification by the lipid peroxidation product 4-hydroxynonenal
Title: Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140721 (e-PCR)
- UniSTS:222787

PMC55400P2 (e-PCR)
- UniSTS:273339

RH137238 (e-PCR)
- UniSTS:219326

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables isocitrate dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables isocitrate dehydrogenase (NADP+) activity	TAS Traceable Author Statement more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in female gonad development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glyoxylate cycle	IEA Inferred from Electronic Annotation more info
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isocitrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in isocitrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isocitrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isocitrate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isocitrate dehydrogenase [NADP] cytoplasmic

Names: IDH; IDP; Isocitrate dehydrogenase 1, soluble; NADP(+)-specific ICDH; cytosolic NADP-isocitrate dehydrogenase; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase 1 (NADP+), soluble; oxalosuccinate decarboxylase

NP_113698.1

EC 1.1.1.42

XP_006245111.1

EC 1.1.1.42

XP_008765298.1

EC 1.1.1.42

XP_063122699.1

EC 1.1.1.42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031510.1 → NP_113698.1 isocitrate dehydrogenase [NADP] cytoplasmic

See identical proteins and their annotated locations for NP_113698.1

Status: PROVISIONAL

Source sequence(s)

L35317

UniProtKB/Swiss-Prot

P41562, P80300

UniProtKB/TrEMBL

A0A8L2QA85, A6IPJ5

Conserved Domains (1) summary

PTZ00435
Location:1 → 411

PTZ00435; isocitrate dehydrogenase; Provisional