Stx2 syntaxin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stx2provided by RGD
Official Full Name: syntaxin 2provided by RGD
Primary source: RGD:2558
See related: Ensembl:ENSRNOG00000000936 AllianceGenome:RGD:2558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Epim
Summary: Enables SNARE binding activity. Involved in several processes, including digestive tract morphogenesis; microvillus assembly; and midbody abscission. Located in midbody and transport vesicle. Is active in synapse. Orthologous to human STX2 (syntaxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 55.3), Spleen (RPKM 49.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (33315447..33350788)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (27678744..27714751)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (31324203..31360249)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-124a aggravates lipopolysaccharide-induced cardiac dysfunction and the miR-124a/STX2 pathway might serve as the potential diagnostic and therapeutic targets for septic cardiac dysfunction.
Title: PMicroRNA-124a regulates LPS-induced septic cardiac dysfunction by targeting STX2.
These data provide evidence for EPIM and SOX9 functioning by mutual negative feedback to regulate attributes of the quiescent or activated state of HSCs.
Title: Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.
Epimorphin has morphogenetic effects on several epithelial tissues, including those of lung.
Title: Epimorphin expression in a rat model of pulmonary hypoplasia associated with congenital diaphragmatic hernia.
Epimorphin regulates bile duct formation of WB-F344 cells through effects on RhoA and C/EBPbeta, implicating a dual aspect of this morphoregulator in bile duct epithelial morphogenesis.
Title: Role of epimorphin in bile duct formation of rat liver epithelial stem-like cells: involvement of small G protein RhoA and C/EBPβ.
Epimorphin regulates bile duct formation via effects on mitosis orientation
Title: Epimorphin regulates bile duct formation via effects on mitosis orientation in rat liver epithelial stem-like cells.
Epimorphin elicits hepatocyte spheroids by inducing proteases in rodent hepatocytes through NF-kappaB.
Title: Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB.
anti-oxidative function of epimorphin is dramatic and is likely mediated by the activation of EGF receptors and the MEK/extracellular signal-regulated kinase and PI3 kinase/Akt signaling pathways
Title: Morphogenic protein epimorphin protects intestinal epithelial cells from oxidative stress by the activation of EGF receptor and MEK/ERK, PI3 kinase/Akt signals.
In conclusion, epimorphin is a factor that induces differentiation of hepatic stem-like cells through epithelial-mesenchymal cell contact.
Title: Epimorphin is involved in differentiation of rat hepatic stem-like cells through cell-cell contact.
expression in intestinal myofibroblasts induces epithelial morphogenesis
Title: Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis.
pIgA-R traffics through postendosomal rab3D-, rab11a-, and syntaxin 2-associated compartments, implicating these proteins in the regulation of transcytosis.
Title: Intracellular accumulation of pIgA-R and regulators of transcytotic trafficking in cholestatic rat hepatocytes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stx2 (e-PCR), detects polymorphism
- UniSTS:506687

RH94687 (e-PCR)
- UniSTS:119934

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cornified envelope assembly	IEA Inferred from Electronic Annotation more info
involved_in cornified envelope assembly	ISO Inferred from Sequence Orthology more info
involved_in digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular transport	TAS Traceable Author Statement more info	PubMed
involved_in microvillus assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in midbody abscission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	TAS Traceable Author Statement more info	PubMed
involved_in vesicle targeting	TAS Traceable Author Statement more info	PubMed
involved_in vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: syntaxin-2

Names: epimorphin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415751.1 → NP_001402680.1 syntaxin-2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J0S6

Related

ENSRNOP00000085955.1, ENSRNOT00000099417.1
NM_012748.2 → NP_036880.2 syntaxin-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J0S7, G3V632

Related

ENSRNOP00000001242.1, ENSRNOT00000001242.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

33315447..33350788

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598270.3 → XP_017453759.2 syntaxin-2 isoform X3
XM_006249253.5 → XP_006249315.2 syntaxin-2 isoform X3
XM_063271077.1 → XP_063127147.1 syntaxin-2 isoform X1
XM_017598271.3 → XP_017453760.1 syntaxin-2 isoform X4

UniProtKB/TrEMBL

A0A0H2UHU9, Q7TS57

Related

ENSRNOP00000092669.1

Conserved Domains (3) summary

cd00179
Location:31 → 182

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

pfam00804
Location:31 → 227

Syntaxin; Syntaxin

cl22856
Location:192 → 227

SNARE; SNARE motif
XM_039089101.2 → XP_038945029.1 syntaxin-2 isoform X2

UniProtKB/Swiss-Prot

P50279, Q08846, Q08847, Q08848

UniProtKB/TrEMBL

A6J0S5

Conserved Domains (2) summary

pfam00804
Location:31 → 228

Syntaxin

cl22856
Location:196 → 262

SNARE; SNARE motif
XM_039089103.2 → XP_038945031.1 syntaxin-2 isoform X5

Conserved Domains (1) summary

cl22856
Location:26 → 60

SNARE; SNARE motif