Sfxn1 sideroflexin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sfxn1provided by RGD
Official Full Name: sideroflexin 1provided by RGD
Primary source: RGD:1308482
See related: Ensembl:ENSRNOG00000018279 AllianceGenome:RGD:1308482
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SLC64A1
Summary: Predicted to enable D-serine transmembrane transporter activity and L-serine transmembrane transporter activity. Predicted to be involved in D-serine transport; L-serine transport; and serine import into mitochondrion. Predicted to act upstream of or within erythrocyte differentiation and iron ion transport. Predicted to be located in mitochondrion. Predicted to be integral component of mitochondrial inner membrane. Orthologous to human SFXN1 (sideroflexin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 466.1), Liver (RPKM 145.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (10491315..10527793, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (10486250..10522640, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (11046588..11082219, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SFXN1is a potential SCIRR69-interacting protein in endoplasmic reticulum stress.
Title: Identification of Novel SCIRR69-Interacting Proteins During ER Stress Using SILAC-Immunoprecipitation Quantitative Proteomics Approach.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-alanine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-serine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-serine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-alanine transport	IEA Inferred from Electronic Annotation more info
involved_in L-alanine transport	ISO Inferred from Sequence Orthology more info
involved_in L-alanine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-serine transport	IEA Inferred from Electronic Annotation more info
involved_in L-serine transport	ISO Inferred from Sequence Orthology more info
involved_in L-serine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of one-carbon metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of one-carbon metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in serine import into mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in serine import into mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in serine import into mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in serine import into mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sideroflexin-1

Names: TCC; solute carrier family 64 member 1; tricarboxylate carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.