Efs embryonal Fyn-associated substrate [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Efsprovided by RGD
Official Full Name: embryonal Fyn-associated substrateprovided by RGD
Primary source: RGD:1308966
See related: Ensembl:ENSRNOG00000042029 AllianceGenome:RGD:1308966
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SH3 domain binding activity. Predicted to be involved in actin filament reorganization; cell migration; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Orthologous to human EFS (embryonal Fyn-associated substrate). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 41.7), Lung (RPKM 33.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32362401..32374490, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28392417..28403016, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33579952..33590217, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH130004 (e-PCR)
- UniSTS:213292

RH137137 (e-PCR)
- UniSTS:219225

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: embryonal Fyn-associated substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106033.2 → NP_001099503.1 embryonal Fyn-associated substrate

See identical proteins and their annotated locations for NP_001099503.1

Status: PROVISIONAL

Source sequence(s)

BC161942

UniProtKB/TrEMBL

A0A8I6ANS3, B1WBZ1

Related

ENSRNOP00000083448.1, ENSRNOT00000104834.1

Conserved Domains (2) summary

cd12003
Location:8 → 70

SH3_EFS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Embryonal Fyn-associated Substrate

pfam12026
Location:372 → 556

DUF3513; Domain of unknown function (DUF3513)