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    Nsd1 nuclear receptor binding SET domain protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306764, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Nsd1provided by RGD
    Official Full Name
    nuclear receptor binding SET domain protein 1provided by RGD
    Primary source
    RGD:1307748
    See related
    Ensembl:ENSRNOG00000016680 AllianceGenome:RGD:1307748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including histone-lysine N-methyltransferase activity; nuclear receptor binding activity; and zinc ion binding activity. Predicted to be involved in histone methylation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within gastrulation with mouth forming second; regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; and regulation of protein modification process. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 292.0), Spleen (RPKM 243.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17p14
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9317085..9431528, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9311963..9426373, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9840859..9955391, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 Neighboring gene RAB24, member RAS oncogene family Neighboring gene uncharacterized LOC134482677 Neighboring gene fibroblast growth factor receptor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia. Shiba N, et al. Genes Chromosomes Cancer, 2013 Jul. PMID 23630019
    2. Further Evidence of Contrasting Phenotypes Caused by Reciprocal Deletions and Duplications: Duplication of NSD1 Causes Growth Retardation and Microcephaly. Rosenfeld JA, et al. Mol Syndromol, 2013 Jan. PMID 23599694, Free PMC Article
    3. A transposon-based analysis of gene mutations related to skin cancer development. Quintana RM, et al. J Invest Dermatol, 2013 Jan. PMID 22832494
    4. Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Berdasco M, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 20018718, Free PMC Article
    5. Familial gigantism caused by an NSD1 mutation. van Haelst MM, et al. Am J Med Genet A, 2005 Nov 15. PMID 16222665

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K36 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K20 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gastrulation with mouth forming second ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase, H3 lysine-36 specific
    Names
    histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
    NP_001388465.1
    XP_006253683.1
    XP_006253684.1
    XP_006253685.1
    XP_006253686.1
    XP_006253689.1
    XP_008769713.1
    XP_038951546.1
    XP_038951547.1
    XP_038951548.1
    XP_038951549.1
    XP_038951550.1
    XP_038951551.1
    XP_038951553.1
    XP_063132407.1
    XP_063132408.1
    XP_063132409.1
    XP_063132410.1
    XP_063132411.1
    XP_063132412.1
    XP_063132413.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401536.1 → NP_001388465.1  histone-lysine N-methyltransferase, H3 lysine-36 specific

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6AMN8
      Related
      ENSRNOP00000094644.1, ENSRNOT00000118233.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9317085..9431528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095620.2 → XP_038951548.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4, A6KAU7, D4AA06
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1483 → 1577
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03247
      Location:1952 → 2324
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:1183 → 1316
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1274 → 1316
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1321 → 1367
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1368 → 1421
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1438 → 1477
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1849 → 1891
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1670 → 1811
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1630 → 1668
      AWS; AWS domain
      pfam17982
      Location:1890 → 1939
      C5HCH; NSD Cys-His rich domain

    2. XM_006253624.5 → XP_006253686.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006253686.1

      UniProtKB/TrEMBL
      A0A8I6A1J6, A0A8I6AMN8, A6KAU6
      Conserved Domains (9) summary
      cd05837
      Location:319 → 429
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1752 → 1846
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1889 → 1939
      AWS; associated with SET domains
      smart00317
      Location:1940 → 2063
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15648
      Location:1543 → 1585
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1590 → 1636
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1637 → 1690
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1707 → 1746
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2118 → 2160
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

    3. XM_063276340.1 → XP_063132410.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4

    4. XM_063276337.1 → XP_063132407.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMN8

    5. XM_039095619.2 → XP_038951547.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4, A6KAU7, D4AA06
      Related
      ENSRNOP00000077028.1
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1483 → 1577
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03247
      Location:1952 → 2324
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:1183 → 1316
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1274 → 1316
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1321 → 1367
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1368 → 1421
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1438 → 1477
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1849 → 1891
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1670 → 1811
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1630 → 1668
      AWS; AWS domain
      pfam17982
      Location:1890 → 1939
      C5HCH; NSD Cys-His rich domain

    6. XM_006253621.5 → XP_006253683.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006253683.1

      UniProtKB/TrEMBL
      A0A8I6A1J6, A0A8I6AMN8, A6KAU6
      Conserved Domains (9) summary
      cd05837
      Location:319 → 429
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1752 → 1846
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1889 → 1939
      AWS; associated with SET domains
      smart00317
      Location:1940 → 2063
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15648
      Location:1543 → 1585
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1590 → 1636
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1637 → 1690
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1707 → 1746
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2118 → 2160
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

    7. XM_063276341.1 → XP_063132411.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4

    8. XM_063276339.1 → XP_063132409.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMN8

    9. XM_063276343.1 → XP_063132413.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4

    10. XM_063276338.1 → XP_063132408.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMN8

    11. XM_006253623.4 → XP_006253685.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006253685.1

      UniProtKB/TrEMBL
      A0A8I6A1J6, A0A8I6AMN8, A6KAU6
      Conserved Domains (9) summary
      cd05837
      Location:319 → 429
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1752 → 1846
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1889 → 1939
      AWS; associated with SET domains
      smart00317
      Location:1940 → 2063
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15648
      Location:1543 → 1585
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1590 → 1636
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1637 → 1690
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1707 → 1746
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2118 → 2160
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

    12. XM_039095618.2 → XP_038951546.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4, A6KAU7, D4AA06
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1483 → 1577
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03247
      Location:1952 → 2324
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:1183 → 1316
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1274 → 1316
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1321 → 1367
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1368 → 1421
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1438 → 1477
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1849 → 1891
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1670 → 1811
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1630 → 1668
      AWS; AWS domain
      pfam17982
      Location:1890 → 1939
      C5HCH; NSD Cys-His rich domain

    13. XM_006253622.5 → XP_006253684.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_006253684.1

      UniProtKB/TrEMBL
      A0A8I6A1J6, A0A8I6AMN8, A6KAU6
      Related
      ENSRNOP00000084557.1
      Conserved Domains (9) summary
      cd05837
      Location:319 → 429
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1752 → 1846
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1889 → 1939
      AWS; associated with SET domains
      smart00317
      Location:1940 → 2063
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15648
      Location:1543 → 1585
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1590 → 1636
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1637 → 1690
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1707 → 1746
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2118 → 2160
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

    14. XM_039095621.2 → XP_038951549.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4, A6KAU7, D4AA06
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1483 → 1577
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03247
      Location:1952 → 2324
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:1183 → 1316
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1274 → 1316
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1321 → 1367
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1368 → 1421
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1438 → 1477
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1849 → 1891
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1670 → 1811
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1630 → 1668
      AWS; AWS domain
      pfam17982
      Location:1890 → 1939
      C5HCH; NSD Cys-His rich domain

    15. XM_039095622.2 → XP_038951550.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4, A6KAU7, D4AA06
      Conserved Domains (12) summary
      cd05837
      Location:50 → 160
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1483 → 1577
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03247
      Location:1952 → 2324
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:1183 → 1316
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1274 → 1316
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1321 → 1367
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1368 → 1421
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1438 → 1477
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1849 → 1891
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1670 → 1811
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1630 → 1668
      AWS; AWS domain
      pfam17982
      Location:1890 → 1939
      C5HCH; NSD Cys-His rich domain

    16. XM_008771491.4 → XP_008769713.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

      See identical proteins and their annotated locations for XP_008769713.1

      UniProtKB/TrEMBL
      A0A8I6A1J6, A0A8I6AMN8, A6KAU6
      Related
      ENSRNOP00000057648.2
      Conserved Domains (9) summary
      cd05837
      Location:319 → 429
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1752 → 1846
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1889 → 1939
      AWS; associated with SET domains
      smart00317
      Location:1940 → 2063
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15648
      Location:1543 → 1585
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1590 → 1636
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1637 → 1690
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1707 → 1746
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:2118 → 2160
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

    17. XM_063276342.1 → XP_063132412.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBL4

    18. XM_039095623.2 → XP_038951551.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

      UniProtKB/TrEMBL
      A6KAU7, D4AA06
      Conserved Domains (12) summary
      cd05837
      Location:14 → 124
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1447 → 1541
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      PHA03247
      Location:1916 → 2288
      PHA03247; large tegument protein UL36; Provisional
      COG5034
      Location:1147 → 1280
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15648
      Location:1238 → 1280
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1285 → 1331
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1332 → 1385
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1402 → 1441
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15659
      Location:1813 → 1855
      PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd19210
      Location:1634 → 1775
      SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
      pfam17907
      Location:1594 → 1632
      AWS; AWS domain
      pfam17982
      Location:1854 → 1903
      C5HCH; NSD Cys-His rich domain

    19. XM_006253627.5 → XP_006253689.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X4

      See identical proteins and their annotated locations for XP_006253689.1

      Conserved Domains (9) summary
      cd05837
      Location:319 → 429
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1752 → 1846
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:1889 → 1939
      AWS; associated with SET domains
      smart00317
      Location:1940 → 2063
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15648
      Location:1543 → 1585
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      cd15650
      Location:1590 → 1636
      PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15653
      Location:1637 → 1690
      PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cd15656
      Location:1707 → 1746
      PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
      cl22851
      Location:2118 → 2152
      PHD_SF; PHD finger superfamily

    20. XM_039095625.2 → XP_038951553.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X5

      Conserved Domains (1) summary
      cd05837
      Location:319 → 429
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107337.1: Suppressed sequence

      Description
      NM_001107337.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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