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    Ssh3 slingshot protein phosphatase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365396, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ssh3provided by RGD
    Official Full Name
    slingshot protein phosphatase 3provided by RGD
    Primary source
    RGD:1308679
    See related
    Ensembl:ENSRNOG00000018878 AllianceGenome:RGD:1308679
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm. Orthologous to human SSH3 (slingshot protein phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 110.7), Kidney (RPKM 89.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ssh3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210986604..210994975, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201557167..201565577, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219511908..219519398, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAD9 checkpoint clamp component A Neighboring gene DNA polymerase delta 4, accessory subunit Neighboring gene uncharacterized LOC103691274 Neighboring gene ankyrin repeat domain 13D Neighboring gene G protein-coupled receptor kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase Slingshot homolog 3
    Names
    SSH-3L
    SSH-like protein 3
    slingshot homolog 3
    NP_001012217.1
    XP_038941428.1
    XP_038941431.1
    XP_038941444.1
    XP_038941454.1
    XP_038941487.1
    XP_063125903.1
    XP_063125906.1
    XP_063125910.1
    XP_063125914.1
    XP_063125917.1
    XP_063125918.1
    XP_063125925.1
    XP_063125928.1
    XP_063125929.1
    XP_063125931.1
    XP_063125932.1
    XP_063125934.1
    XP_063125939.1
    XP_063125941.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012217.1 → NP_001012217.1  protein phosphatase Slingshot homolog 3

      See identical proteins and their annotated locations for NP_001012217.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083600
      UniProtKB/Swiss-Prot
      Q5XIS1
      Conserved Domains (3) summary
      cd11652
      Location:3 → 256
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:326 → 461
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:269 → 317
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210986604..210994975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269844.1 → XP_063125914.1  protein phosphatase Slingshot homolog 3 isoform X7

    2. XM_063269833.1 → XP_063125903.1  protein phosphatase Slingshot homolog 3 isoform X3

    3. XM_039085503.2 → XP_038941431.1  protein phosphatase Slingshot homolog 3 isoform X2

      Conserved Domains (3) summary
      cd11652
      Location:32 → 279
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14571
      Location:350 → 493
      DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
      pfam08766
      Location:296 → 347
      DEK_C; DEK C terminal domain

    4. XM_039085500.2 → XP_038941428.1  protein phosphatase Slingshot homolog 3 isoform X1

      Conserved Domains (3) summary
      cd11652
      Location:32 → 279
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14571
      Location:352 → 495
      DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
      pfam08766
      Location:298 → 349
      DEK_C; DEK C terminal domain

    5. XM_063269847.1 → XP_063125917.1  protein phosphatase Slingshot homolog 3 isoform X9

    6. XM_063269861.1 → XP_063125931.1  protein phosphatase Slingshot homolog 3 isoform X14

    7. XM_063269859.1 → XP_063125929.1  protein phosphatase Slingshot homolog 3 isoform X13

    8. XM_063269855.1 → XP_063125925.1  protein phosphatase Slingshot homolog 3 isoform X11

    9. XM_063269840.1 → XP_063125910.1  protein phosphatase Slingshot homolog 3 isoform X5

    10. XM_063269862.1 → XP_063125932.1  protein phosphatase Slingshot homolog 3 isoform X14

    11. XM_063269858.1 → XP_063125928.1  protein phosphatase Slingshot homolog 3 isoform X12

    12. XM_063269848.1 → XP_063125918.1  protein phosphatase Slingshot homolog 3 isoform X10

    13. XM_039085526.2 → XP_038941454.1  protein phosphatase Slingshot homolog 3 isoform X8

      UniProtKB/TrEMBL
      A6HYW8
      Conserved Domains (3) summary
      cd11652
      Location:3 → 257
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14571
      Location:324 → 467
      DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
      pfam08766
      Location:270 → 321
      DEK_C; DEK C terminal domain

    14. XM_039085516.2 → XP_038941444.1  protein phosphatase Slingshot homolog 3 isoform X6

      UniProtKB/TrEMBL
      F1LR78
      Related
      ENSRNOP00000025546.7
      Conserved Domains (3) summary
      cd11652
      Location:3 → 257
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14571
      Location:328 → 471
      DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
      pfam08766
      Location:274 → 325
      DEK_C; DEK C terminal domain

    15. XM_063269836.1 → XP_063125906.1  protein phosphatase Slingshot homolog 3 isoform X4

    16. XM_063269864.1 → XP_063125934.1  protein phosphatase Slingshot homolog 3 isoform X15

    17. XM_063269871.1 → XP_063125941.1  protein phosphatase Slingshot homolog 3 isoform X16

    18. XM_063269869.1 → XP_063125939.1  protein phosphatase Slingshot homolog 3 isoform X16

    19. XM_039085559.2 → XP_038941487.1  protein phosphatase Slingshot homolog 3 isoform X17

      Conserved Domains (3) summary
      cd11652
      Location:32 → 279
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      pfam08766
      Location:298 → 349
      DEK_C; DEK C terminal domain
      cl28904
      Location:352 → 435
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIS1.1 GenPept UniProtKB/Swiss-Prot:Q5XIS1

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