Acvr2b activin A receptor type 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acvr2bprovided by RGD
Official Full Name: activin A receptor type 2Bprovided by RGD
Primary source: RGD:2028
See related: Ensembl:ENSRNOG00000014477 AllianceGenome:RGD:2028
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 28.7), Kidney (RPKM 21.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (128016589..128056193)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (119138901..119178477)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (128087308..128126776)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the structure of an activin class member, GDF11, in complex with the type II receptor ActRIIB and the type I receptor Alk5, is reported.
Title: Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.
Expression of ActRIIB mRNA is increased in muscle, mesenteric fat and brown adipose tissue of sedentary diabetic rats compared with sedentary control rats.
Title: Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise.
activin A receptor type IIB mRNA expression in brown adipose tissue was higher in exercised high-fat fed rats compared with a sedentary high-fat fed group
Title: Post-exercise changes in myostatin and actRIIB expression in obese insulin-resistant rats.
In a rat model of HF, we demonstrated a concerted induction of the gene expression of activin betaA and activin receptors IA, IB, IIA, and IIB after myocardial infarction.
Title: Elevated levels of activin A in heart failure: potential role in myocardial remodeling.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC202382P2 (e-PCR)
- UniSTS:271889

MARC_4816-4817:991938566:3 (e-PCR)
- UniSTS:231088

Acvr2b (e-PCR), detects polymorphism
- UniSTS:496632

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	IDA Inferred from Direct Assay more info	PubMed
enables activin binding	IEA Inferred from Electronic Annotation more info
enables activin binding	ISO Inferred from Sequence Orthology more info
enables activin binding	TAS Traceable Author Statement more info	PubMed
enables activin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity, type II	ISO Inferred from Sequence Orthology more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables inhibin binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase activator activity	IEA Inferred from Electronic Annotation more info
enables kinase activator activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
NOT enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in artery development	IEA Inferred from Electronic Annotation more info
involved_in artery development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in embryonic foregut morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic foregut morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in gastrulation with mouth forming second	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lymphangiogenesis	IEA Inferred from Electronic Annotation more info
involved_in lymphangiogenesis	ISO Inferred from Sequence Orthology more info
involved_in lymphatic endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in lymphatic endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mesoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in organ growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organ growth	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to glucose	ISO Inferred from Sequence Orthology more info
involved_in retina vasculature development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in retina vasculature development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in sexual reproduction	NAS Non-traceable Author Statement more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in skeletal system morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in venous blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in venous blood vessel development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activin receptor type-2B

Names: ACTR-IIB; ActRIIB type II activin receptor B; Activine receptor 2b (transmembrane serine kinase); activin A receptor, type IIB; activin receptor IIB; activin receptor type IIB

NP_113742.1

EC 2.7.11.30

XP_006244134.1

EC 2.7.11.30

XP_038936802.1

EC 2.7.11.30

XP_038936803.1

EC 2.7.11.30

XP_038936804.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031554.1 → NP_113742.1 activin receptor type-2B precursor

See identical proteins and their annotated locations for NP_113742.1

Status: PROVISIONAL

Source sequence(s)

BC097358

UniProtKB/Swiss-Prot

P38445, Q4V8J8

UniProtKB/TrEMBL

A0A0G2JSN4, A6I3W5

Related

ENSRNOP00000019777.4, ENSRNOT00000019777.7

Conserved Domains (3) summary

smart00220
Location:198 → 471

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14140
Location:194 → 484

STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor

pfam01064
Location:39 → 117

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

128016589..128056193

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244072.5 → XP_006244134.1 activin receptor type-2B isoform X2

See identical proteins and their annotated locations for XP_006244134.1

UniProtKB/TrEMBL

A0A8I6A9R2, A6I3W4, A6I3W6

Related

ENSRNOP00000090538.1

Conserved Domains (3) summary

smart00220
Location:222 → 495

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14140
Location:218 → 508

STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor

pfam01064
Location:39 → 117

Activin_recp; Activin types I and II receptor domain
XM_039080874.2 → XP_038936802.1 activin receptor type-2B isoform X1

UniProtKB/TrEMBL

A6I3W6

Conserved Domains (2) summary

cd14140
Location:227 → 517

STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor

pfam01064
Location:50 → 119

Activin_recp; Activin types I and II receptor domain
XM_039080876.2 → XP_038936804.1 activin receptor type-2B isoform X4

UniProtKB/Swiss-Prot

P38445, Q4V8J8

Conserved Domains (2) summary

cd14140
Location:195 → 485

STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor

pfam01064
Location:50 → 119

Activin_recp; Activin types I and II receptor domain
XM_039080875.2 → XP_038936803.1 activin receptor type-2B isoform X3

UniProtKB/Swiss-Prot

P38445, Q4V8J8

Conserved Domains (2) summary

cd14140
Location:203 → 493

STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor

pfam01064
Location:50 → 119

Activin_recp; Activin types I and II receptor domain