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    Ahsp alpha hemoglobin stabilizing protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293522, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ahspprovided by RGD
    Official Full Name
    alpha hemoglobin stabilizing proteinprovided by RGD
    Primary source
    RGD:1306725
    See related
    AllianceGenome:RGD:1306725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eraf
    Summary
    Predicted to enable hemoglobin binding activity. Predicted to be involved in erythrocyte differentiation; protein folding; and protein stabilization. Predicted to be active in cytoplasm. Orthologous to human AHSP (alpha hemoglobin stabilizing protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 4235.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ahsp in Genome Data Viewer
    Location:
    1q37
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192310306..192315943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182879901..182885508)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199720038..199721010)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transforming growth factor beta 1 induced transcript 1 Neighboring gene solute carrier family 5 member 2 Neighboring gene RUS family member 1 Neighboring gene uncharacterized LOC120099940 Neighboring gene uncharacterized LOC134485178 Neighboring gene uncharacterized LOC103691239

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An abundant erythroid protein that stabilizes free alpha-haemoglobin. Kihm AJ, et al. Nature, 2002 Jun 13. PMID 12066189
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hemoglobin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-hemoglobin-stabilizing protein
    Names
    erythroid associated factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106299.1 → NP_001099769.1  alpha-hemoglobin-stabilizing protein

      See identical proteins and their annotated locations for NP_001099769.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A9UMW3
      Conserved Domains (1) summary
      pfam09236
      Location:5 → 91
      AHSP; Alpha-haemoglobin stabilizing protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      192310306..192315943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107525.2 → XP_038963453.1  alpha-hemoglobin-stabilizing protein isoform X1

      UniProtKB/TrEMBL
      A9UMW3
      Conserved Domains (1) summary
      pfam09236
      Location:5 → 91
      AHSP; Alpha-haemoglobin stabilizing protein

    2. XM_063286306.1 → XP_063142376.1  alpha-hemoglobin-stabilizing protein isoform X1

      UniProtKB/TrEMBL
      A9UMW3
    Nucleotide Protein Strain
    Heading Accession and Version

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