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    Palld palladin, cytoskeletal associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360205, updated on 11-Apr-2024

    Summary

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    Symbol
    Palldprovided by RGD
    Full Name
    palladin, cytoskeletal associated proteinprovided by RGD
    Primary source
    RGD:2322545
    See related
    Ensembl:ENSRNOG00000010107 AllianceGenome:RGD:2322545
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Palldl1; AABR07025295.1
    Summary
    Enables cytoskeletal protein binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of podosome assembly; and trophoblast giant cell differentiation. Located in several cellular components, including Z disc; actin cytoskeleton; and axonal growth cone. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 195.1), Heart (RPKM 175.2) and 8 other tissues See more
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    Genomic context

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    See Palld in Genome Data Viewer
    Location:
    16p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (33238943..33632236)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28228006..28621349)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (31865712..31948168)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482494 Neighboring gene DEXD/H-box helicase 60 Neighboring gene uncharacterized LOC120097508 Neighboring gene uncharacterized LOC120097383 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482542 Neighboring gene carbonyl reductase 4 Neighboring gene SH3 domain containing ring finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A role for the cytoskeleton-associated protein palladin in neurite outgrowth. Boukhelifa M, et al. Mol Biol Cell, 2001 Sep. PMID 11553711, Free PMC Article
    2. Palladin is expressed preferentially in excitatory terminals in the rat central nervous system. Hwang SJ, et al. J Comp Neurol, 2001 Jul 23. PMID 11438925
    3. Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells. Salaria SN, et al. Cancer Biol Ther, 2007 Mar. PMID 17404500, Free PMC Article
    4. A critical role for palladin in astrocyte morphology and response to injury. Boukhelifa M, et al. Mol Cell Neurosci, 2003 Aug. PMID 12932445
    5. Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration. Jin L, et al. Circ Res, 2007 Mar 30. PMID 17322171

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
      Title: [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in epithelial cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within keratinocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ruffle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trophoblast giant cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palladin; palladin, cytoskeletal associated protein
    Names
    palladin-like
    palladin-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      33238943..33632236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094916.2 → XP_038950844.1  palladin isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADH4
      Conserved Domains (6) summary
      pfam07679
      Location:449 → 546
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:1161 → 1164
      Ig; Ig strand A [structural motif]
      cd05892
      Location:1260 → 1351
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:1027 → 1118
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20972
      Location:278 → 369
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:1161 → 1251
      Ig; Immunoglobulin domain

    2. XM_039094914.2 → XP_038950842.1  palladin isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADH4
      Conserved Domains (6) summary
      pfam07679
      Location:449 → 546
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:1161 → 1164
      Ig; Ig strand A [structural motif]
      cd05892
      Location:1260 → 1351
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:1027 → 1118
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20972
      Location:278 → 369
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:1161 → 1251
      Ig; Immunoglobulin domain

    3. XM_039094915.2 → XP_038950843.1  palladin isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADH4
      Conserved Domains (6) summary
      pfam07679
      Location:449 → 546
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:1144 → 1147
      Ig; Ig strand A [structural motif]
      cd05892
      Location:1243 → 1334
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:1010 → 1101
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cd20972
      Location:278 → 369
      IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:1144 → 1234
      Ig; Immunoglobulin domain

    4. XM_039094917.2 → XP_038950845.1  palladin isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQM3
      Related
      ENSRNOP00000080820.1
      Conserved Domains (5) summary
      pfam07679
      Location:59 → 156
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:771 → 774
      Ig; Ig strand A [structural motif]
      cd05892
      Location:870 → 961
      IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
      cd05893
      Location:637 → 728
      IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:771 → 861
      Ig; Immunoglobulin domain

    5. XM_008771231.4 → XP_008769453.1  palladin isoform X5

      See identical proteins and their annotated locations for XP_008769453.1

      Conserved Domains (3) summary
      cd00096
      Location:315 → 384
      Ig; Immunoglobulin domain
      cd05893
      Location:548 → 622
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:432 → 522
      I-set; Immunoglobulin I-set domain

    6. XM_008771232.4 → XP_008769454.1  palladin isoform X6

      See identical proteins and their annotated locations for XP_008769454.1

      UniProtKB/TrEMBL
      A0A8I6A9U3
      Related
      ENSRNOP00000088354.1
      Conserved Domains (3) summary
      cd00096
      Location:298 → 367
      Ig; Immunoglobulin domain
      cd05893
      Location:531 → 605
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:415 → 505
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein Strain
    Heading Accession and Version

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