Slc17a3 solute carrier family 17 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc17a3provided by RGD
Official Full Name: solute carrier family 17 member 3provided by RGD
Primary source: RGD:628815
See related: Ensembl:ENSRNOG00000032745 AllianceGenome:RGD:628815
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rnpt4
Summary: Predicted to enable several functions, including anion transmembrane transporter activity; toxin transmembrane transporter activity; and urate transmembrane transporter activity. Predicted to be involved in organic anion transport; urate metabolic process; and xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in apical plasma membrane; endoplasmic reticulum membrane; and perinuclear region of cytoplasm. Predicted to be active in lysosome. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 354.3) and Liver (RPKM 290.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (41698679..41729057, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (41270804..41300132, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (43518760..43545160, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

effects of volume expansion on the renal sodium phosphate cotransporter
Title: Molecular effects of volume expansion on the renal sodium phosphate cotransporter.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables efflux transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:phosphate symporter activity	TAS Traceable Author Statement more info	PubMed
enables toxin transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transport	TAS Traceable Author Statement more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in urate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in urate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-dependent phosphate transport protein 4

Names: Na/Pi cotransporter 4; sodium-phosphate cotransporter; solute carrier family 17 (organic anion transporter), member 3; solute carrier family 17 (sodium phosphate), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153622.2 → NP_705886.1 sodium-dependent phosphate transport protein 4

See identical proteins and their annotated locations for NP_705886.1

Status: PROVISIONAL

Source sequence(s)

AB025223

UniProtKB/TrEMBL

A6KLL0, Q8CJH9

Related

ENSRNOP00000029152.4, ENSRNOT00000029626.6

Conserved Domains (2) summary

cd06174
Location:105 → 482

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:27 → 497

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

41698679..41729057 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253947.5 → XP_006254009.1 sodium-dependent phosphate transport protein 4 isoform X3

UniProtKB/TrEMBL

A6KLL0, Q6AZ69

Conserved Domains (1) summary

cd06174
Location:145 → 493

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
XM_063276121.1 → XP_063132191.1 sodium-dependent phosphate transport protein 4 isoform X8
XM_063276119.1 → XP_063132189.1 sodium-dependent phosphate transport protein 4 isoform X5
XM_006253941.5 → XP_006254003.1 sodium-dependent phosphate transport protein 4 isoform X1

See identical proteins and their annotated locations for XP_006254003.1

UniProtKB/TrEMBL

A6KLL0, Q6AZ69

Conserved Domains (2) summary

cd06174
Location:145 → 522

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:71 → 537

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
XM_063276118.1 → XP_063132188.1 sodium-dependent phosphate transport protein 4 isoform X4
XM_006253942.5 → XP_006254004.1 sodium-dependent phosphate transport protein 4 isoform X1

See identical proteins and their annotated locations for XP_006254004.1

UniProtKB/TrEMBL

A6KLL0, Q6AZ69

Conserved Domains (2) summary

cd06174
Location:145 → 522

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:71 → 537

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
XM_063276120.1 → XP_063132190.1 sodium-dependent phosphate transport protein 4 isoform X6

UniProtKB/TrEMBL

A0A0G2JY28
XM_063276117.1 → XP_063132187.1 sodium-dependent phosphate transport protein 4 isoform X2

UniProtKB/TrEMBL

A6KLL2, E9PTR8
XM_063276116.1 → XP_063132186.1 sodium-dependent phosphate transport protein 4 isoform X1
XM_039095421.2 → XP_038951349.1 sodium-dependent phosphate transport protein 4 isoform X7

Conserved Domains (1) summary

TIGR00894
Location:71 → 394

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter