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    Cbll1 Cbl proto-oncogene like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314028, updated on 2-May-2024

    Summary

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    Official Symbol
    Cbll1provided by RGD
    Official Full Name
    Cbl proto-oncogene like 1provided by RGD
    Primary source
    RGD:1310703
    See related
    Ensembl:ENSRNOG00000007253 AllianceGenome:RGD:1310703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cell-cell adhesion; mRNA methylation; and protein ubiquitination. Predicted to act upstream of or within negative regulation of cell adhesion; positive regulation of cell migration; and positive regulation of endocytosis. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Orthologous to human CBLL1 (Cbl proto-oncogene like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 86.0), Spleen (RPKM 76.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (53798712..53812890, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (48071190..48086174, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (50772718..50786861, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene dihydrolipoamide dehydrogenase Neighboring gene solute carrier family 26 member 3 Neighboring gene uncharacterized LOC102555378 Neighboring gene solute carrier family 26 member 4 Neighboring gene uncharacterized LOC108351220

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Fujita Y, et al. Nat Cell Biol, 2002 Mar. PMID 11836526
    2. Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. Mukherjee M, et al. EMBO J, 2012 Mar 7. PMID 22252131, Free PMC Article
    3. Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal. Wen J, et al. Mol Cell, 2018 Mar 15. PMID 29547716, Free PMC Article
    4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Hakai
    Names
    Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
    Casitas B-lineage lymphoma-like 1
    Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1
    Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
    NP_001101488.1
    NP_001386492.1
    NP_001386493.1
    XP_006240050.1
    XP_038968140.1
    XP_038968141.1
    XP_038968142.1
    XP_038968144.1
    XP_038968146.1
    XP_063117967.1
    XP_063117968.1
    XP_063117969.1
    XP_063117970.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108018.1 → NP_001101488.1  E3 ubiquitin-protein ligase Hakai isoform 3

      See identical proteins and their annotated locations for NP_001101488.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HB48, D3ZS02
      Related
      ENSRNOP00000094608.1, ENSRNOT00000102801.1
      Conserved Domains (1) summary
      pfam13923
      Location:106 → 145
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_001399563.1 → NP_001386492.1  E3 ubiquitin-protein ligase Hakai isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001399564.1 → NP_001386493.1  E3 ubiquitin-protein ligase Hakai isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      53798712..53812890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239988.5 → XP_006240050.1  E3 ubiquitin-protein ligase Hakai isoform X5

      UniProtKB/TrEMBL
      D3ZS02
      Conserved Domains (1) summary
      pfam13923
      Location:105 → 144
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. XM_063261900.1 → XP_063117970.1  E3 ubiquitin-protein ligase Hakai isoform X9

    3. XM_063261899.1 → XP_063117969.1  E3 ubiquitin-protein ligase Hakai isoform X8

    4. XM_063261898.1 → XP_063117968.1  E3 ubiquitin-protein ligase Hakai isoform X7

    5. XM_039112218.2 → XP_038968146.1  E3 ubiquitin-protein ligase Hakai isoform X6

      UniProtKB/TrEMBL
      A0A8I6AJZ8
      Conserved Domains (2) summary
      cd16508
      Location:57 → 98
      RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
      pfam18408
      Location:111 → 142
      zf_Hakai; C2H2 Hakai zinc finger domain

    6. XM_039112214.2 → XP_038968142.1  E3 ubiquitin-protein ligase Hakai isoform X4

      UniProtKB/TrEMBL
      D3ZS02
      Conserved Domains (2) summary
      cd16508
      Location:155 → 196
      RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
      pfam18408
      Location:209 → 240
      zf_Hakai; C2H2 Hakai zinc finger domain

    7. XM_063261897.1 → XP_063117967.1  E3 ubiquitin-protein ligase Hakai isoform X6

    8. XM_039112216.2 → XP_038968144.1  E3 ubiquitin-protein ligase Hakai isoform X3

      UniProtKB/TrEMBL
      D3ZS02
      Conserved Domains (2) summary
      cd16508
      Location:154 → 195
      RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
      pfam18408
      Location:208 → 239
      zf_Hakai; C2H2 Hakai zinc finger domain

    9. XM_039112213.2 → XP_038968141.1  E3 ubiquitin-protein ligase Hakai isoform X2

      UniProtKB/TrEMBL
      D3ZS02
      Conserved Domains (2) summary
      cd16508
      Location:157 → 198
      RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
      pfam18408
      Location:211 → 242
      zf_Hakai; C2H2 Hakai zinc finger domain

    10. XM_039112212.2 → XP_038968140.1  E3 ubiquitin-protein ligase Hakai isoform X1

      UniProtKB/TrEMBL
      D3ZS02
      Conserved Domains (2) summary
      cd16508
      Location:158 → 199
      RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
      pfam18408
      Location:212 → 243
      zf_Hakai; C2H2 Hakai zinc finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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