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    Smoc2 SPARC related modular calcium binding 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292401, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Smoc2provided by RGD
    Official Full Name
    SPARC related modular calcium binding 2provided by RGD
    Primary source
    RGD:1306681
    See related
    Ensembl:ENSRNOG00000014166 AllianceGenome:RGD:1306681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; extracellular matrix binding activity; and heparin binding activity. Predicted to be involved in several processes, including positive regulation of endothelial cell chemotaxis; positive regulation of signal transduction; and positive regulation of vascular wound healing. Predicted to act upstream of or within positive regulation of cell-substrate adhesion. Predicted to be located in interstitial matrix. Predicted to be active in basement membrane and extracellular space. Orthologous to human SMOC2 (SPARC related modular calcium binding 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 475.0), Muscle (RPKM 153.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smoc2 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (63935627..64064952)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (55262472..55391804)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (56242289..56374106)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FERM domain containing 1 Neighboring gene dishevelled-binding antagonist of beta-catenin 2 Neighboring gene transfer RNA proline (anticodon AGG) 46 Neighboring gene uncharacterized LOC120097714 Neighboring gene thrombospondin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C. Liu D, et al. Cell Death Dis, 2022 Dec 13. PMID 36513634, Free PMC Article
    2. Characterization of SMOC-2, a modular extracellular calcium-binding protein. Vannahme C, et al. Biochem J, 2003 Aug 1. PMID 12741954, Free PMC Article
    3. The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity. Rocnik EF, et al. J Biol Chem, 2006 Aug 11. PMID 16774925
    4. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C.
      Title: SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosaminoglycan binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interstitial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SPARC-related modular calcium-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106215.2 → NP_001099685.1  SPARC-related modular calcium-binding protein 2 precursor

      See identical proteins and their annotated locations for NP_001099685.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168953
      UniProtKB/TrEMBL
      A0A0G2K0K9, B5DF75
      Related
      ENSRNOP00000071488.1, ENSRNOT00000079718.2
      Conserved Domains (5) summary
      smart00280
      Location:39 → 84
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:215 → 281
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd16241
      Location:304 → 417
      EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
      pfam00086
      Location:90 → 153
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam16597
      Location:154 → 214
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      63935627..64064952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227958.4 → XP_006228020.1  SPARC-related modular calcium-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0K9, F7FPL2
      Related
      ENSRNOP00000019317.6
      Conserved Domains (5) summary
      smart00280
      Location:39 → 84
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:226 → 292
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd16241
      Location:315 → 428
      EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)
      pfam00086
      Location:90 → 153
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam16597
      Location:154 → 225
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain
    Nucleotide Protein Strain
    Heading Accession and Version

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