U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309419, updated on 2-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pip5k1bprovided by RGD
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase type 1 betaprovided by RGD
    Primary source
    RGD:1310914
    See related
    Ensembl:ENSRNOG00000015232 AllianceGenome:RGD:1310914
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pip5k1a
    Summary
    Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphorylation. Predicted to act upstream of or within phosphatidylinositol biosynthetic process. Predicted to be located in cytosol and uropod. Orthologous to human PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 84.3), Spleen (RPKM 62.4) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pip5k1b in Genome Data Viewer
    Location:
    1q51
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (231331836..231610092, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (221907220..222183672, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (242168462..242441247, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483979 Neighboring gene tight junction protein 2 Neighboring gene uncharacterized LOC120100005 Neighboring gene frataxin Neighboring gene uncharacterized LOC134483980 Neighboring gene dynein light chain Tctex-type 1, pseudogene1 Neighboring gene PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 Neighboring gene transmembrane protein 252 Neighboring gene phosphoglucomutase 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses. Lee SY, et al. Exp Mol Med, 2010 Sep 30. PMID 20720456, Free PMC Article
    2. Phosphatidylinositol 4-phosphate 5-kinase α negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells. Liu T, et al. Exp Mol Med, 2013 Mar 29. PMID 23538529, Free PMC Article
    3. The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. Vasudevan L, et al. J Cell Sci, 2009 Jul 15. PMID 19549683, Free PMC Article
    4. An isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells. Mañes S, et al. FASEB J, 2010 Sep. PMID 20442317
    5. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. Ishihara H, et al. J Biol Chem, 1996 Sep 27. PMID 8798574

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIP5Kalpha acts as a negative regulator of nerve growth factor-induced neurite outgrowth by inhibiting PI3K/Akt signaling pathway in PC12 cells.
      Title: Phosphatidylinositol 4-phosphate 5-kinase α negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells.
    2. Ganglioside treatment of primary astrocytes enhances PIP5Kalpha expression. PIP5Kalpha knockdown attenuates ganglioside-induced inflammatory responses.
      Title: Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses.
    3. The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.
      Title: The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC105713

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in uropod IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in uropod ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase type-1 beta
    Names
    PIP5K1-beta
    PIP5KIalpha
    PIP5KIbeta
    phosphatidylinositol 4-phosphate 5-kinase type I alpha
    phosphatidylinositol 4-phosphate 5-kinase type I beta
    phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
    ptdIns(4)P-5-kinase 1 beta
    ptdIns(4)P-5-kinase beta
    NP_001012761.1
    XP_038936135.1
    XP_063120787.1
    XP_063120790.1
    XP_063120793.1
    XP_063120797.1
    XP_063120800.1
    XP_063120802.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012743.1 → NP_001012761.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta

      See identical proteins and their annotated locations for NP_001012761.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090349
      UniProtKB/Swiss-Prot
      Q5CZZ9
      UniProtKB/TrEMBL
      A0A096MK77
      Related
      ENSRNOP00000063506.2, ENSRNOT00000068645.5
      Conserved Domains (1) summary
      smart00330
      Location:53 → 393
      PIPKc; Phosphatidylinositol phosphate kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      231331836..231610092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080207.2 → XP_038936135.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2

      UniProtKB/TrEMBL
      A0A096MK77
      Conserved Domains (1) summary
      cd17307
      Location:27 → 400
      PIPKc_PIP5K1B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins

    2. XM_063264723.1 → XP_063120793.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4

      UniProtKB/Swiss-Prot
      Q5CZZ9

    3. XM_063264717.1 → XP_063120787.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1

    4. XM_063264730.1 → XP_063120800.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X6

    5. XM_063264727.1 → XP_063120797.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X5

    6. XM_063264720.1 → XP_063120790.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3

    7. XM_063264732.1 → XP_063120802.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5CZZ9.1 GenPept UniProtKB/Swiss-Prot:Q5CZZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous