Myl3 myosin light chain 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myl3provided by RGD
Official Full Name: myosin light chain 3provided by RGD
Primary source: RGD:3142
See related: Ensembl:ENSRNOG00000020955 AllianceGenome:RGD:3142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MLClV; Mylc1v; rVMLC1
Summary: Enables cytoskeletal motor activity. Involved in cardiac muscle contraction and skeletal muscle tissue development. Part of myosin complex. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 23530.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (119617077..119623215)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (110738669..110744814)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (119030852..119036996)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
Title: Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
Slowing of shortening velocity in type IIb fibers with hindlimb unloading involves a decrease in the relative amount of Myl3.
Title: The roles of myosin ATPase activity and myosin light chain relative content in the slowing of type IIB fibers with hindlimb unweighting in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94602 (e-PCR)
- UniSTS:119850

D8Arb21 (e-PCR)
- UniSTS:240433

D8Wox8 (e-PCR)
- UniSTS:239945

RH138771 (e-PCR)
- UniSTS:220858

D8Wox9 (e-PCR)
- UniSTS:119230

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin monomer binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in regulation of striated muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in A band	IEA Inferred from Electronic Annotation more info
located_in A band	ISO Inferred from Sequence Orthology more info
located_in I band	IEA Inferred from Electronic Annotation more info
located_in I band	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin light chain 3

Names: MLC1SB; Myosin light chain 3, alkali, cardiac ventricles; myosin alkali light chain 1, ventricular; myosin, light chain 3, alkali; myosin, light chain 3, alkali; ventricular, skeletal, slow; myosin, light polypeptide 3; ventricular myosin light chain 1; ventricular, skeletal, slow; ventricular/slow twitch myosin alkali light chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012606.2 → NP_036738.1 myosin light chain 3

See identical proteins and their annotated locations for NP_036738.1

Status: PROVISIONAL

Source sequence(s)

BC081832

UniProtKB/Swiss-Prot

P16409

UniProtKB/TrEMBL

A0A8I5ZM89, A6I3G7

Related

ENSRNOP00000028458.2, ENSRNOT00000028458.6

Conserved Domains (1) summary

PTZ00184
Location:49 → 199

PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

119617077..119623215

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243917.5 → XP_006243979.3 myosin light chain 3 isoform X1

UniProtKB/Swiss-Prot

P16409

UniProtKB/TrEMBL

A0A8I5ZM89, A6I3G7

Conserved Domains (1) summary

PTZ00184
Location:49 → 199

PTZ00184; calmodulin; Provisional