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    Gmcl1 germ cell-less 1, spermatogenesis associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312516, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Gmcl1provided by RGD
    Official Full Name
    germ cell-less 1, spermatogenesis associatedprovided by RGD
    Primary source
    RGD:1359265
    See related
    Ensembl:ENSRNOG00000017838 AllianceGenome:RGD:1359265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gcl
    Summary
    This gene encodes a nuclear envelope protein that contains a broad-complex, tramtrack and bric a brac/ Pox virus and Zinc finger (BTB/POZ) protein-protein interaction domain. In mouse, this gene is expressed at high levels in the testis, and null mutant mice exhibit morphologically abnormal sperm that have chromatin condensation defects. These defects result in significantly impaired fertility, demonstrating a role for this gene in male germ cell development in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Biased expression in Testes (RPKM 129.8), Thymus (RPKM 96.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmcl1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120697976..120737267, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119140598..119179891, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118494997..118534301, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene max dimerization protein 1 Neighboring gene uncharacterized LOC134486607 Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27 Neighboring gene annexin A4 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene uncharacterized LOC134486606

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility. Maekawa M, et al. Arch Histol Cytol, 2004 Nov. PMID 15700541
    2. Reduced human germ cell-less (HGCL) expression in azoospermic men with severe germinal cell impairment. Kleiman SE, et al. J Androl, 2003 Sep-Oct. PMID 12954656
    3. Mouse germ cell-less as an essential component for nuclear integrity. Kimura T, et al. Mol Cell Biol, 2003 Feb. PMID 12556490, Free PMC Article
    4. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Masuhara M, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927808
    5. Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. Leatherman JL, et al. Mech Dev, 2000 Apr. PMID 10727854

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    germ cell-less protein-like 1
    Names
    germ cell-less homolog 1
    germ cell-less, spermatogenesis associated 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010956.3 → NP_001010956.1  germ cell-less protein-like 1 isoform 2

      See identical proteins and their annotated locations for NP_001010956.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the 3'-terminal exon and has a 3' end that extends into an intron compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BP492225, FM064983, JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K533, Q5I286
      Related
      ENSRNOP00000073273.2, ENSRNOT00000081201.2
      Conserved Domains (3) summary
      smart00225
      Location:107 → 206
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:211 → 281
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:96 → 203
      BTB; BTB/POZ domain

    2. NM_001033931.2 → NP_001029103.1  germ cell-less protein-like 1 isoform 1

      See identical proteins and their annotated locations for NP_001029103.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BP492225, FM064983, JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K533, A6IAZ0, F7ERJ6, Q5I287
      Related
      ENSRNOP00000024414.5, ENSRNOT00000024414.6
      Conserved Domains (2) summary
      cd18305
      Location:91 → 205
      BTB_POZ_GCL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins
      cd18495
      Location:206 → 283
      BACK_GCL; BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      120697976..120737267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236832.5 → XP_006236894.1  germ cell-less protein-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K533, A0A8I6B2P7
      Related
      ENSRNOP00000095491.1
      Conserved Domains (2) summary
      smart00225
      Location:107 → 206
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:96 → 203
      BTB; BTB/POZ domain

    RNA

    1. XR_010065645.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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