Dgkg diacylglycerol kinase, gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dgkgprovided by RGD
Official Full Name: diacylglycerol kinase, gammaprovided by RGD
Primary source: RGD:2499
See related: Ensembl:ENSRNOG00000001796 AllianceGenome:RGD:2499
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dagk3; DGKIII; DGK-III
Summary: Enables diacylglycerol kinase activity. Involved in neuron development. Located in membrane. Orthologous to human DGKG (diacylglycerol kinase gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 253.6), Brain (RPKM 95.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (91888957..92083715)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (78384212..78579158)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (81971585..82165111)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cellular expression and subcellular localization of diacylglycerol kinase gamma in rat brain.
Title: Cellular expression and subcellular localization of diacylglycerol kinase γ in rat brain.
Knockdown of Dgkg, but not DGK-alpha, inhibited degranulation in mast cells.
Title: Diacylglycerol kinase γ regulates antigen-induced mast cell degranulation by mediating Ca(2+) influxes.
In brain, DGKgamma showed sustained expression throughout the postnatal developmental periods. And In the hippocampal pyramidal cell, Dgkg localized in the cytosol.
Title: Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain.
localization and activation of the functionally correlated kinases, gammaPKC and DGKgamma, are spatio-temporally orchestrated by their direct association and phosphorylation, contributing to subtype-specific regulation of DGKgamma and DAG signaling
Title: Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Cebr1 (e-PCR)
- UniSTS:518696

D11Rat82 (e-PCR), detects polymorphism
- UniSTS:226428

RH127760 (e-PCR)
- UniSTS:211070

BF399547 (e-PCR)
- UniSTS:247718

RH94733 (e-PCR)
- UniSTS:119980

G35720 (e-PCR)
- UniSTS:12207

D11Got74 (e-PCR)
- UniSTS:114096

Dgkg (e-PCR), detects polymorphism
- UniSTS:506845

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent diacylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycerolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in lipid phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase C signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of dendrite development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: diacylglycerol kinase gamma

Names: 88 kDa diacylglycerol kinase; DAG kinase gamma; DGK-gamma; Diacylglycerol kinase 3 (gamma); diglyceride kinase gamma

NP_037258.1

EC 2.7.1.107

XP_006248600.1

EC 2.7.1.107

XP_006248602.1

EC 2.7.1.107

XP_038943971.1

EC 2.7.1.107

XP_038943972.1

EC 2.7.1.107

XP_063126382.1

EC 2.7.1.107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013126.2 → NP_037258.1 diacylglycerol kinase gamma

See identical proteins and their annotated locations for NP_037258.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P49620

UniProtKB/TrEMBL

A6JS57

Related

ENSRNOP00000002452.5, ENSRNOT00000002452.6

Conserved Domains (8) summary

smart00109
Location:333 → 380

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00045
Location:575 → 749

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:433 → 554

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:433 → 759

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00029
Location:269 → 318

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:176 → 245

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:177 → 241

EF-hand_7; EF-hand domain pair

pfam14513
Location:5 → 172

DAG_kinase_N; Diacylglycerol kinase N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

91888957..92083715

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270312.1 → XP_063126382.1 diacylglycerol kinase gamma isoform X2
XM_006248538.5 → XP_006248600.1 diacylglycerol kinase gamma isoform X1

UniProtKB/TrEMBL

A0A8I6A589, A6JS57

Related

ENSRNOP00000088510.1

Conserved Domains (7) summary

smart00045
Location:536 → 710

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:394 → 515

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

COG1597
Location:394 → 720

LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

cd00029
Location:269 → 318

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:176 → 245

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:177 → 241

EF-hand_7; EF-hand domain pair

pfam14513
Location:5 → 172

DAG_kinase_N; Diacylglycerol kinase N-terminus
XM_006248540.5 → XP_006248602.1 diacylglycerol kinase gamma isoform X3

Conserved Domains (7) summary

smart00109
Location:333 → 380

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00046
Location:433 → 554

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:269 → 318

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:176 → 245

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:177 → 241

EF-hand_7; EF-hand domain pair

pfam14513
Location:5 → 172

DAG_kinase_N; Diacylglycerol kinase N-terminus

cl02440
Location:575 → 607

DAGK_acc; Diacylglycerol kinase accessory domain
XM_039088043.2 → XP_038943971.1 diacylglycerol kinase gamma isoform X4

Conserved Domains (4) summary

smart00045
Location:408 → 582

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:266 → 387

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:9 → 78

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl00040
Location:85 → 158

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_039088044.2 → XP_038943972.1 diacylglycerol kinase gamma isoform X4

Conserved Domains (4) summary

smart00045
Location:408 → 582

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:266 → 387

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00051
Location:9 → 78

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl00040
Location:85 → 158

C1; protein kinase C conserved region 1 (C1 domain) superfamily