Suclg2 succinate-CoA ligase GDP-forming subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Suclg2provided by RGD
Official Full Name: succinate-CoA ligase GDP-forming subunit betaprovided by RGD
Primary source: RGD:1305008
See related: Ensembl:ENSRNOG00000005686 AllianceGenome:RGD:1305008
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GDP binding activity and succinate-CoA ligase (GDP-forming) activity. Involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Part of succinate-CoA ligase complex (GDP-forming). Orthologous to human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1366.4), Liver (RPKM 796.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (129623833..129893937, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (128067031..128337146, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (127552100..127824970, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D4Mit16 (e-PCR), detects polymorphism
- UniSTS:119592

RH136847 (e-PCR)
- UniSTS:218936

RH142916 (e-PCR)
- UniSTS:232163

AA850481 (e-PCR)
- UniSTS:250363

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables succinate-CoA ligase (ADP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (GDP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (GDP-forming) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in succinate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in succinyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of succinate-CoA ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of succinate-CoA ligase complex (GDP-forming)	IDA Inferred from Direct Assay more info	PubMed
part_of succinate-CoA ligase complex (GDP-forming)	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

Names: succinate-CoA ligase, GDP-forming, beta subunit; succinate-Coenzyme A ligase, GDP-forming, beta subunit; succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

NP_001094220.1

EC 6.2.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100750.1 → NP_001094220.1 succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

See identical proteins and their annotated locations for NP_001094220.1

Status: VALIDATED

Source sequence(s)

BC160886

UniProtKB/TrEMBL

B1H270, Q68FT4

Related

ENSRNOP00000060990.3, ENSRNOT00000068274.3

Conserved Domains (3) summary

PRK00696
Location:41 → 422

sucC; succinyl-CoA synthetase subunit beta; Provisional

pfam00549
Location:308 → 422

Ligase_CoA; CoA-ligase

pfam08442
Location:41 → 249

ATP-grasp_2; ATP-grasp domain