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    Slc25a23 solute carrier family 25 member 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301113, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Slc25a23provided by RGD
    Official Full Name
    solute carrier family 25 member 23provided by RGD
    Primary source
    RGD:1588586
    See related
    Ensembl:ENSRNOG00000047781 AllianceGenome:RGD:1588586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP transmembrane transporter activity. Predicted to be involved in calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response. Predicted to act upstream of or within several processes, including cellular response to calcium ion; regulation of oxidative phosphorylation; and urea homeostasis. Predicted to be located in mitochondrion. Orthologous to human SLC25A23 (solute carrier family 25 member 23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 252.3), Liver (RPKM 238.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1969633..1985365, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1882636..1898369, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9987988..10003599)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase isoenzyme 5 Neighboring gene KH-type splicing regulatory protein Neighboring gene solute carrier family 25, member 41 Neighboring gene crumbs cell polarity complex component 3 Neighboring gene DENN domain containing 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Hoffman NE, et al. Mol Biol Cell, 2014 Mar. PMID 24430870, Free PMC Article
    2. Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. Amigo I, et al. J Biol Chem, 2013 Mar 15. PMID 23344948, Free PMC Article
    3. Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash activation. Hou T, et al. Cell Calcium, 2016 May. PMID 26975899
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ATP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial ATP transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular hyperosmotic salinity response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of sequestering of calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within renal system process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial adenyl nucleotide antiporter SLC25A23
    Names
    calcium-binding mitochondrial carrier protein SCaMC-3
    phosphate carrier), member 23
    solute carrier family 25 (mitochondrial carrier
    solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106873.3 → NP_001100343.1  mitochondrial adenyl nucleotide antiporter SLC25A23

      See identical proteins and their annotated locations for NP_001100343.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JVD2, A6KQS8
      Related
      ENSRNOP00000069437.2, ENSRNOT00000086575.2
      Conserved Domains (2) summary
      COG5126
      Location:7 → 142
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:189 → 462
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1969633..1985365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083133.2 → XP_038939061.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X2

      Conserved Domains (3) summary
      COG5126
      Location:7 → 142
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:189 → 426
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:184 → 267
      Mito_carr; Mitochondrial carrier protein

    2. XM_017596319.3 → XP_017451808.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X1

      UniProtKB/TrEMBL
      M0R4V4
      Related
      ENSRNOP00000064402.2
    Nucleotide Protein Strain
    Heading Accession and Version

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