F12 coagulation factor XII [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: F12provided by RGD
Official Full Name: coagulation factor XIIprovided by RGD
Primary source: RGD:1359175
See related: Ensembl:ENSRNOG00000015139 AllianceGenome:RGD:1359175
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HAF
Summary: Predicted to enable serine-type endopeptidase activity. Involved in blood coagulation. Located in extracellular space. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in angioedema (multiple); cerebrovascular disease (multiple); factor XII deficiency; and myocardial infarction. Orthologous to human F12 (coagulation factor XII). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1746.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9212819..9220664)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9207683..9215530)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9736577..9744420)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FXIIa-kininogen mediated vasoconstriction contributes significantly to CKD hypertension in Brown Norway rats.
Title: Coagulation factor XIIa-kinin-mediated contribution to hypertension of chronic kidney disease.
beta-FXIIa infusion induces both adrenal catecholamine-mediated and adrenally independent increases in peripheral resistance
Title: Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats.
The changes in levels of blood coaagulation factor XII in folic acid deficient rats are reversed by treatment with folic acid.
Title: Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II.

Submit: New GeneRIF Correction

General gene information

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Markers

BE102123 (e-PCR)
- UniSTS:244072

F12 (e-PCR), detects polymorphism
- UniSTS:502724

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Factor XII activation	IEA Inferred from Electronic Annotation more info
involved_in Factor XII activation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in plasma kallikrein-kinin cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in response to misfolded protein	IEA Inferred from Electronic Annotation more info
involved_in response to misfolded protein	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in zymogen activation	IEA Inferred from Electronic Annotation more info
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in rough endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: coagulation factor XII

Names: factor XII; hageman factor

NP_001014028.1

EC 3.4.21.38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014006.1 → NP_001014028.1 coagulation factor XII precursor

See identical proteins and their annotated locations for NP_001014028.1

Status: PROVISIONAL

Source sequence(s)

BC088187

UniProtKB/TrEMBL

A0A0H2UI19

Related

ENSRNOP00000061983.3, ENSRNOT00000066586.3

Conserved Domains (7) summary

smart00020
Location:361 → 597

Tryp_SPc; Trypsin-like serine protease

cd00054
Location:95 → 130

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00061
Location:132 → 170

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00062
Location:40 → 87

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00190
Location:362 → 600

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00008
Location:177 → 207

EGF; EGF-like domain

pfam00051
Location:216 → 294

Kringle; Kringle domain