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    Agxt2 alanine-glyoxylate aminotransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83784, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Agxt2provided by RGD
    Official Full Name
    alanine-glyoxylate aminotransferase 2provided by RGD
    Primary source
    RGD:621767
    See related
    Ensembl:ENSRNOG00000017821 AllianceGenome:RGD:621767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AGT2
    Summary
    Predicted to enable alanine-glyoxylate transaminase activity and beta-alanine-pyruvate transaminase activity. Predicted to be involved in carboxylic acid metabolic process and positive regulation of nitric oxide biosynthetic process. Predicted to be located in mitochondrion. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 3234.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agxt2 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61063416..61104828)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (59336252..59377664)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60337667..60379144)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485719 Neighboring gene prolactin receptor Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene biogenesis of ribosomes BRX1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distribution of D-3-aminoisobutyrate-pyruvate aminotransferase in the rat brain. Abe M, et al. BMC Neurosci, 2014 Apr 27. PMID 24766736, Free PMC Article
    2. Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver. Tamaki N, et al. Eur J Biochem, 1990 Apr 20. PMID 2158891
    3. Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers. Kittel A, et al. PLoS One, 2014. PMID 24586340, Free PMC Article
    4. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. Rodionov RN, et al. J Biol Chem, 2010 Feb 19. PMID 20018850, Free PMC Article
    5. Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver. Tamaki N, et al. Methods Enzymol, 2000. PMID 10989446

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA.
      Title: Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA.
    2. Our results suggest that D-AIB AT is distributed in the examined- just the regions and may play an important role there.
      Title: Distribution of D-3-aminoisobutyrate-pyruvate aminotransferase in the rat brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alanine-glyoxylate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine-glyoxylate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alanine-glyoxylate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alanine-glyoxylate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-alanine-pyruvate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-alanine-pyruvate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine catabolic process, by transamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-alanine catabolic process, by transamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N(omega),N(omega)-dimethyl-L-arginine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine biosynthetic process, by transamination of glyoxylate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glyoxylate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyoxylate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alanine--glyoxylate aminotransferase 2, mitochondrial
    Names
    (R)-3-amino-2-methylpropionate--pyruvate transaminase
    AGT 2
    D-3-aminoisobutyrate-pyruvate aminotransferase
    D-AIBAT
    D-beta-aminoisobutyrate-pyruvate aminotransferase
    beta-ALAAT II
    beta-alanine-pyruvate aminotransferase
    NP_114023.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031835.2 → NP_114023.1  alanine--glyoxylate aminotransferase 2, mitochondrial

      See identical proteins and their annotated locations for NP_114023.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081765
      UniProtKB/Swiss-Prot
      O08616, Q642F1, Q64565
      UniProtKB/TrEMBL
      A6KJT6, A6KJT7
      Related
      ENSRNOP00000024035.5, ENSRNOT00000024035.8
      Conserved Domains (2) summary
      cd00610
      Location:65 → 503
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      TIGR00707
      Location:79 → 503
      argD; transaminase, acetylornithine/succinylornithine family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      61063416..61104828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64565.2 GenPept UniProtKB/Swiss-Prot:Q64565

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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