Dmrt1 doublesex and mab-3 related transcription factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dmrt1provided by RGD
Official Full Name: doublesex and mab-3 related transcription factor 1provided by RGD
Primary source: RGD:621640
See related: Ensembl:ENSRNOG00000016075 AllianceGenome:RGD:621640
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in intracellular signal transduction. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human DMRT1 (doublesex and mab-3 related transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 46.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q51

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (232569179..232667646)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (223142859..223241333)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (243477403..243582629)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXL2, a transcription factor required for differentiation of the ovary, repressed Dmrt1 promoter through the -3.2 kb/-2.8 kb regulatory region, offering a potential mechanism for Dmrt1 transcriptional silencing in granulosa cells.
Title: Distinct transcriptional mechanisms direct expression of the rat Dmrt1 promoter in sertoli cells and germ cells of transgenic mice.
Sp1, Sp3, and Egr1 transcription factors play a critical role in Dmrt1 regulation in the testis
Title: Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Dmrt1 (e-PCR), detects polymorphism
- UniSTS:464667

Dmrt1 (e-PCR), detects polymorphism
- UniSTS:516702

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Sertoli cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Sertoli cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Sertoli cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental process involved in reproduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within germ cell migration	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in male germ cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of male gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male sex determination	ISO Inferred from Sequence Orthology more info
involved_in male sex differentiation	ISO Inferred from Sequence Orthology more info
involved_in male sex differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of meiosis I	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of male gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of meiosis I	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of nodal signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: doublesex- and mab-3-related transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053706.1 → NP_446158.1 doublesex- and mab-3-related transcription factor 1

See identical proteins and their annotated locations for NP_446158.1

Status: PROVISIONAL

Source sequence(s)

AF379608

UniProtKB/TrEMBL

F7FNR4, Q925A6

Related

ENSRNOP00000021779.1, ENSRNOT00000021779.4

Conserved Domains (2) summary

pfam00751
Location:70 → 116

DM; DM DNA binding domain

pfam12374
Location:128 → 200

Dmrt1; Double-sex mab3 related transcription factor 1