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    Als2cl ALS2 C-terminal like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316017, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Als2clprovided by RGD
    Official Full Name
    ALS2 C-terminal likeprovided by RGD
    Primary source
    RGD:1305208
    See related
    Ensembl:ENSRNOG00000033921 AllianceGenome:RGD:1305208
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305208
    Summary
    Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to act upstream of or within endosome organization and protein localization. Predicted to be located in cytoplasmic vesicle. Orthologous to human ALS2CL (ALS2 C-terminal like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 65.9), Lung (RPKM 52.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q32
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119746498..119762824)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110863753..110884434)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119156081..119176680)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene serine protease 50 Neighboring gene transmembrane inner ear Neighboring gene uncharacterized LOC120094265 Neighboring gene family with sequence similarity 240 member A Neighboring gene uncharacterized LOC134480239

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. Hadano S, et al. FEBS Lett, 2004 Sep 24. PMID 15388334
    2. ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics. Suzuki-Utsunomiya K, et al. Biochem Biophys Res Commun, 2007 Mar 9. PMID 17239822
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ALS2 C-terminal-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119746498..119762824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082651.2 → XP_038938579.1  ALS2 C-terminal-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEV4, D3ZG75
      Conserved Domains (3) summary
      PLN03185
      Location:357 → 550
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      cl19569
      Location:835 → 937
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl17171
      Location:223 → 321
      PH-like; Pleckstrin homology-like domain

    2. XM_039082659.2 → XP_038938587.1  ALS2 C-terminal-like protein isoform X2

      Conserved Domains (2) summary
      PLN03185
      Location:357 → 550
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      cl17171
      Location:223 → 321
      PH-like; Pleckstrin homology-like domain

    3. XM_039082661.2 → XP_038938589.1  ALS2 C-terminal-like protein isoform X3

      Conserved Domains (2) summary
      PLN03185
      Location:357 → 550
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      cl17171
      Location:223 → 321
      PH-like; Pleckstrin homology-like domain

    4. XM_039082662.2 → XP_038938590.1  ALS2 C-terminal-like protein isoform X4

      Conserved Domains (2) summary
      PLN03185
      Location:357 → 550
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      cl17171
      Location:223 → 321
      PH-like; Pleckstrin homology-like domain

    5. XM_039082664.2 → XP_038938592.1  ALS2 C-terminal-like protein isoform X6

      Conserved Domains (2) summary
      PLN03185
      Location:357 → 394
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      cl17171
      Location:223 → 321
      PH-like; Pleckstrin homology-like domain

    6. XM_039082663.2 → XP_038938591.1  ALS2 C-terminal-like protein isoform X5

      Conserved Domains (2) summary
      PLN03185
      Location:2 → 187
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      cl19569
      Location:472 → 574
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    RNA

    1. XR_005488472.2 RNA Sequence

    2. XR_005488473.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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