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    Bst1 bone marrow stromal cell antigen 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81506, updated on 2-May-2024

    Summary

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    Official Symbol
    Bst1provided by RGD
    Official Full Name
    bone marrow stromal cell antigen 1provided by RGD
    Primary source
    RGD:620344
    See related
    Ensembl:ENSRNOG00000003064 AllianceGenome:RGD:620344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ADP-ribosyl cyclase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; and phosphorus-oxygen lyase activity. Predicted to be involved in several processes, including positive regulation of B cell proliferation; regulation of neutrophil chemotaxis; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in uropod. Predicted to be extrinsic component of membrane. Predicted to be active in plasma membrane. Orthologous to human BST1 (bone marrow stromal cell antigen 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 247.1), Spleen (RPKM 125.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71466179..71482671, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (67253706..67270203, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (71798218..71814540, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 Neighboring gene CD38 molecule Neighboring gene uncharacterized LOC108352765 Neighboring gene F-box and leucine-rich repeat protein 5 Neighboring gene cytochrome c, somatic pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CD157 is an important mediator of neutrophil adhesion and migration. Funaro A, et al. Blood, 2004 Dec 15. PMID 15328157
    2. Human BST-1 expressed on myeloid cells functions as a receptor molecule. Okuyama Y, et al. Biochem Biophys Res Commun, 1996 Nov 21. PMID 8941363
    3. Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1 (BST-1) from the islets of Langerhans. Furuya Y, et al. Gene, 1995 Nov 20. PMID 8522202
    4. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Kaisho T, et al. Proc Natl Acad Sci U S A, 1994 Jun 7. PMID 8202488, Free PMC Article
    5. ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1. Hirata Y, et al. FEBS Lett, 1994 Dec 19. PMID 7805847

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphorus-oxygen lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in uropod IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in uropod ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
    Names
    ADP-ribosyl cyclase 2
    BST-1
    bone marrow stromal antigen 1
    cADPr hydrolase 2
    cyclic ADP-ribose hydrolase 2
    NP_110475.1
    XP_038948409.1
    XP_038948410.1
    XP_038948411.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030848.2 → NP_110475.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor

      See identical proteins and their annotated locations for NP_110475.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q63072
      UniProtKB/TrEMBL
      A6IJP1, F1LSX3
      Related
      ENSRNOP00000004094.6, ENSRNOT00000004094.7
      Conserved Domains (1) summary
      pfam02267
      Location:41 → 269
      Rib_hydrolayse; ADP-ribosyl cyclase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      71466179..71482671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092482.2 → XP_038948410.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X2

      UniProtKB/TrEMBL
      F1LSX3
      Conserved Domains (1) summary
      pfam02267
      Location:41 → 238
      Rib_hydrolayse; ADP-ribosyl cyclase

    2. XM_039092481.2 → XP_038948409.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1

      Conserved Domains (1) summary
      pfam02267
      Location:41 → 236
      Rib_hydrolayse; ADP-ribosyl cyclase

    3. XM_039092483.2 → XP_038948411.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X3

      Conserved Domains (1) summary
      cl08346
      Location:41 → 179
      Rib_hydrolase; ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38

    RNA

    1. XR_005493016.2 RNA Sequence

    2. XR_005493017.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63072.1 GenPept UniProtKB/Swiss-Prot:Q63072

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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