Adamdec1 ADAM-like, decysin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamdec1provided by MGI
Official Full Name: ADAM-like, decysin 1provided by MGI
Primary source: MGI:MGI:1917650
See related: Ensembl:ENSMUSG00000022057 AllianceGenome:MGI:1917650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dcsn; 2210414L24Rik
Summary: Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Is expressed in foregut-midgut junction; hindgut; midgut; and stomach. Orthologous to human ADAMDEC1 (ADAM like decysin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 67.7), colon adult (RPKM 23.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 35.69 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (68800829..68819535, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (68563387..68582072, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
Title: Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.
Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRalpha(+) Cells Is a New Marker for Inflammatory Bowel Disease.
Title: Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRα(+) Cells Is a New Marker for Inflammatory Bowel Disease.
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.
Title: Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.
protects the bowel from chemical and bacterial insults, failure of which may predispose to Crohn's disease
Title: Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADAM DEC1

Names: ADAM-like protein decysin-1; a disintegrin and metalloproteinase domain-like protein decysin-1; decysin; disintegrin metalloprotease (decysin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021475.3 → NP_067450.1 ADAM DEC1 precursor

See identical proteins and their annotated locations for NP_067450.1

Status: VALIDATED

Source sequence(s)

AC154706, CT025563

Consensus CDS

CCDS49532.1

UniProtKB/Swiss-Prot

Q9R0X2

UniProtKB/TrEMBL

Q3U0T4

Related

ENSMUSP00000022641.8, ENSMUST00000022641.9

Conserved Domains (4) summary

cd04269
Location:217 → 408

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:217 → 411

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:54 → 170

Pep_M12B_propep; Reprolysin family propeptide

cl10507
Location:427 → 460

Disintegrin; Disintegrin