U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MORN2 MORN repeat containing 2 [ Homo sapiens (human) ]

    Gene ID: 729967, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MORN2provided by HGNC
    Official Full Name
    MORN repeat containing 2provided by HGNC
    Primary source
    HGNC:HGNC:30166
    See related
    Ensembl:ENSG00000188010 AllianceGenome:HGNC:30166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOPT; BLOCK27
    Summary
    Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in acrosomal vesicle and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 66.4), kidney (RPKM 22.6) and 16 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MORN2 in Genome Data Viewer
    Location:
    2p22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (38875976..38882709)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (38884462..38891196)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (39103117..39109850)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene DExH-box helicase 57 Neighboring gene argininosuccinate synthetase 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 4728 Neighboring gene uncharacterized LOC105374470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15611 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:39102285-39103268 Neighboring gene RNA, U6 small nuclear 851, pseudogene Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene uncharacterized LOC105374471 Neighboring gene RNA, 7SL, cytoplasmic 96, pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Screening in planarians identifies MORN2 as a key component in LC3-associated phagocytosis and resistance to bacterial infection. Abnave P, et al. Cell Host Microbe, 2014 Sep 10. PMID 25211076
    2. Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis. Choi YJ, et al. Theriogenology, 2010 Feb. PMID 19913896
    3. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages. Morita M, et al. Biol Open, 2020 Jun 23. PMID 32414768, Free PMC Article
    4. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. Yu LR, et al. J Proteome Res, 2007 Nov. PMID 17924679
    5. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Landers JE, et al. Proc Natl Acad Sci U S A, 2009 Jun 2. PMID 19451621, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MOPT is associated with dynamic regulation of acrosome biogenesis during late spermiogenesis.
      Title: Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC111382, MGC126130, MGC126131, MGC126132

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    MORN repeat-containing protein 2
    Names
    MORN motif protein in testis
    protein containing single MORN motif in testis

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145450.3 → NP_001138922.2  MORN repeat-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AC018693, KF510812
      Consensus CDS
      CCDS46262.2
      UniProtKB/TrEMBL
      A0A2R8YE86
      Related
      ENSP00000494143.2, ENST00000644631.4
      Conserved Domains (1) summary
      COG4642
      Location:51 → 139
      COG4642; Uncharacterized conserved protein [Function unknown]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      38875976..38882709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      38884462..38891196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_194270.1: Suppressed sequence

      Description
      NM_194270.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q502X0.2 GenPept UniProtKB/Swiss-Prot:Q502X0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous