Acot1 acyl-CoA thioesterase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acot1provided by RGD
Official Full Name: acyl-CoA thioesterase 1provided by RGD
Primary source: RGD:70894
See related: AllianceGenome:RGD:70894
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cte1
Summary: Enables acyl-CoA hydrolase activity. Involved in long-chain fatty acid metabolic process and negative regulation of cardiac muscle cell apoptotic process. Located in cytosol. Orthologous to several human genes including ACOT1 (acyl-CoA thioesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 455.2), Heart (RPKM 286.0) and 9 other tissues See more
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Genomic context

Location:: 6q31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (109367274..109375268)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (103636173..103644167)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (107485088..107493082)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Acot1 expression is transiently upregulated at an early stage of adipocyte maturation, possibly to maintain cytosolic acyl-CoAs below a certain level until the cells acquire their full capability for fat storage.
Title: Expression and distribution of acyl-CoA thioesterases in the white adipose tissue of rats.
ACOT1 plays a crucial protective role in the diabetic heart via PPARalpha/PGC1alpha signaling.
Title: Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling.
ACOT isoform expression may be regulated during brown adipocyte differentiation to support the fat storage and combustion characteristics of this cell type.
Title: Regulated expression of acyl-CoA thioesterases in the differentiation of cultured rat brown adipocytes.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables thiolester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 1

Names: ACH2; CTE-I; LACH2; acyl-CoA thioesterase 1, cytosolic; cytosolic acyl-CoA thioesterase 1; inducible cytosolic acyl-coenzyme A thioester hydrolase; long chain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase; palmitoyl-coenzyme A thioesterase

NP_112605.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031315.2 → NP_112605.1 acyl-coenzyme A thioesterase 1

See identical proteins and their annotated locations for NP_112605.1

Status: PROVISIONAL

Source sequence(s)

Y09334

UniProtKB/TrEMBL

A6JDS5

Conserved Domains (3) summary

pfam04775
Location:17 → 137

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

pfam08840
Location:203 → 410

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

cl21494
Location:145 → 257

Abhydrolase; alpha/beta hydrolases