Idi1 isopentenyl-diphosphate delta isomerase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Idi1provided by RGD
Official Full Name: isopentenyl-diphosphate delta isomerase 1provided by RGD
Primary source: RGD:621835
See related: Ensembl:ENSRNOG00000016690 AllianceGenome:RGD:621835
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable isopentenyl-diphosphate delta-isomerase activity; magnesium ion binding activity; and manganese ion binding activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process. Predicted to act upstream of or within response to stilbenoid. Located in peroxisome. Orthologous to human IDI1 (isopentenyl-diphosphate delta isomerase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 279.1), Brain (RPKM 179.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (66539761..66547524, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (61629592..61637357, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (57976266..57984036, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH139889 (e-PCR)
- UniSTS:221973

RH130561 (e-PCR)
- UniSTS:213845

RH143310 (e-PCR)
- UniSTS:232557

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables isopentenyl-diphosphate delta-isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables isopentenyl-diphosphate delta-isomerase activity	IEA Inferred from Electronic Annotation more info
enables isopentenyl-diphosphate delta-isomerase activity	ISO Inferred from Sequence Orthology more info
enables isopentenyl-diphosphate delta-isomerase activity	TAS Traceable Author Statement more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in dimethylallyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in isopentenyl diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isopentenyl-diphosphate Delta-isomerase 1

Names: IPP isomerase 1; IPPI1; isopentenyl pyrophosphate isomerase 1

NP_445991.2

EC 5.3.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053539.2 → NP_445991.2 isopentenyl-diphosphate Delta-isomerase 1

See identical proteins and their annotated locations for NP_445991.2

Status: VALIDATED

Source sequence(s)

BC089786, BF389837, BP491941, BP500454, FM059509

UniProtKB/TrEMBL

A0A0H2UHN2, A0A8I5ZLV9, A6KRN6

Related

ENSRNOP00000022389.5, ENSRNOT00000022389.7

Conserved Domains (2) summary

COG1443
Location:75 → 278

Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]

cl00447
Location:56 → 283

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...