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    Zfp64 zinc finger protein 64 [ Mus musculus (house mouse) ]

    Gene ID: 22722, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp64provided by MGI
    Official Full Name
    zinc finger protein 64provided by MGI
    Primary source
    MGI:MGI:107342
    See related
    Ensembl:ENSMUSG00000027551 AllianceGenome:MGI:107342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm38422
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of interferon-beta production; positive regulation of interleukin-6 production; and positive regulation of tumor necrosis factor production. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; embryo mesenchyme; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human ZFP64 (ZFP64 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 17.9), ovary adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp64 in Genome Data Viewer
    Location:
    2 H3; 2 88.99 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168735251..168797507, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168893331..168955587, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06472 Neighboring gene spalt like transcription factor 4 Neighboring gene predicted gene 14261 Neighboring gene predicted gene, 25214 Neighboring gene STARR-positive B cell enhancer ABC_E3422 Neighboring gene STARR-positive B cell enhancer ABC_E6025 Neighboring gene STARR-seq mESC enhancer starr_06482 Neighboring gene RIKEN cDNA 1700017J07 gene Neighboring gene predicted gene, 39993

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells. Sakamoto K, et al. J Cell Sci, 2008 May 15. PMID 18430783
    2. A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2. Mack HG, et al. Gene, 1997 Jan 31. PMID 9034307
    3. Genomic structure, chromosomal mapping, and muscle-specific expression of a PH domain-associated intronless gene, cded/lior. Mishra L, et al. Mamm Genome, 1999 Jan. PMID 9892736
    4. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Ewart-Toland A, et al. Nat Genet, 2003 Aug. PMID 12881723
    5. Identification of tooth-specific downstream targets of Runx2. Gaikwad JS, et al. Gene, 2001 Nov 14. PMID 11722849

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mesenchymal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 64
    Names
    zfp-64

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369059.1 → NP_001355988.1  zinc finger protein 64 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL844882
      Consensus CDS
      CCDS89588.1
      UniProtKB/Swiss-Prot
      P97365, Q99KE8, Q9CWR3
      UniProtKB/TrEMBL
      A2AQR3
      Related
      ENSMUSP00000104790.3, ENSMUST00000109162.9
      Conserved Domains (2) summary
      COG5048
      Location:170 → 553
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175 → 195
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001370946.1 → NP_001357875.1  zinc finger protein 64 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL844882
      Conserved Domains (3) summary
      COG5048
      Location:95 → 226
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:97 → 122
      zf-H2C2_2; Zinc-finger double domain

    3. NM_009564.2 → NP_033590.2  zinc finger protein 64 isoform 1

      See identical proteins and their annotated locations for NP_033590.2

      Status: VALIDATED

      Source sequence(s)
      AK146036, BY752610, CX734245
      Consensus CDS
      CCDS50804.1
      UniProtKB/TrEMBL
      A2AQR4
      Related
      ENSMUSP00000085285.5, ENSMUST00000087971.11
      Conserved Domains (4) summary
      COG5048
      Location:149 → 448
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175 → 195
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:159 → 184
      zf-H2C2_2; Zinc-finger double domain
      pfam13912
      Location:422 → 448
      zf-C2H2_6; C2H2-type zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      168735251..168797507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KE8.1 GenPept UniProtKB/Swiss-Prot:Q99KE8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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