Nr2c2 nuclear receptor subfamily 2, group C, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nr2c2provided by RGD
Official Full Name: nuclear receptor subfamily 2, group C, member 2provided by RGD
Primary source: RGD:3201
See related: Ensembl:ENSRNOG00000010536 AllianceGenome:RGD:3201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tr4
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Predicted to be involved in several processes, including positive regulation of embryonic development; positive regulation of myoblast differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; p38MAPK cascade; and spermatogenesis. Predicted to be located in nucleoplasm. Orthologous to human NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 236.9), Brain (RPKM 235.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (126167350..126223942)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (124610216..124666813)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (124005287..124030349)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Testicular orphan receptor 4 induced hepatic stellate cells activation via the regulation of TGF-beta receptor /Smad2/3 signaling pathway.
Title: Testicular orphan receptor 4 induced hepatic stellate cells activation via the regulation of TGF-β receptor Ⅰ/Smad2/3 signaling pathway.
Both in vitro and in vivo data demonstrate the identification of a new pathway, TR4---> phosphoenolpyruvate carboxykinase--->gluconeogenesis--->blood glucose.
Title: Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis.
Together, these findings provide the first in vivo evidence that an orphan nuclear receptor, such as TR4, may play major roles in the RA-mediated apoptosis or differentiation in P19 cells.
Title: Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor.
Together, our data demonstrate that TR4 can enhance apoE gene expression via binding to TR4RE-DR0 in apoE 5' promoter and this TR4 binding is essential for synergistic interaction with another transcription factor, Sp1.
Title: Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region.
expression of TR4 in rat testis is stage dependent and androgen inductive, and TR4 may have an important role in spermatogenesis
Title: Stage dependent and androgen inductive expression of orphan receptor TR4 in rat testis.

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General gene information

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Markers

RH138078 (e-PCR)
- UniSTS:220165

Nr2c2 (e-PCR), detects polymorphism
- UniSTS:144665

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebellum development	ISO Inferred from Sequence Orthology more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of embryonic development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear receptor subfamily 2 group C member 2

Names: TR4 orphan receptor; TR4-NS orphan receptor; orphan nuclear receptor TR4; orphan receptor TR4; testicular receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017323.2 → NP_059019.2 nuclear receptor subfamily 2 group C member 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P55094

UniProtKB/TrEMBL

A6IBC1, G3V7F5

Related

ENSRNOP00000014354.3, ENSRNOT00000014353.6

Conserved Domains (2) summary

cd06952
Location:361 → 582

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:112 → 198

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

126167350..126223942

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108274.2 → XP_038964202.1 nuclear receptor subfamily 2 group C member 2 isoform X2

UniProtKB/Swiss-Prot

P55094

UniProtKB/TrEMBL

A6IBC1, G3V7F5

Conserved Domains (2) summary

cd06952
Location:361 → 582

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:112 → 198

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_039108276.2 → XP_038964204.1 nuclear receptor subfamily 2 group C member 2 isoform X2

UniProtKB/Swiss-Prot

P55094

UniProtKB/TrEMBL

A6IBC1, G3V7F5

Related

ENSRNOP00000082748.1

Conserved Domains (2) summary

cd06952
Location:361 → 582

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:112 → 198

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_039108269.2 → XP_038964197.1 nuclear receptor subfamily 2 group C member 2 isoform X2

UniProtKB/Swiss-Prot

P55094

UniProtKB/TrEMBL

A6IBC1, G3V7F5

Conserved Domains (2) summary

cd06952
Location:361 → 582

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:112 → 198

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_039108266.2 → XP_038964194.1 nuclear receptor subfamily 2 group C member 2 isoform X1

UniProtKB/Swiss-Prot

P55094

UniProtKB/TrEMBL

A0A8I6AGK0, A6IBB9

Related

ENSRNOP00000091661.1

Conserved Domains (2) summary

cd06952
Location:394 → 615

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:145 → 231

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_039108275.2 → XP_038964203.1 nuclear receptor subfamily 2 group C member 2 isoform X2

UniProtKB/Swiss-Prot

P55094

UniProtKB/TrEMBL

A6IBC1, G3V7F5

Conserved Domains (2) summary

cd06952
Location:361 → 582

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:112 → 198

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
XM_039108273.1 → XP_038964201.1 nuclear receptor subfamily 2 group C member 2 isoform X2

UniProtKB/Swiss-Prot

P55094

UniProtKB/TrEMBL

A6IBC1, G3V7F5

Conserved Domains (2) summary

cd06952
Location:361 → 582

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:112 → 198

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers