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    Derl2 derlin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910823, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Derl2provided by RGD
    Official Full Name
    derlin 2provided by RGD
    Primary source
    RGD:6496100
    See related
    Ensembl:ENSRNOG00000055466 AllianceGenome:RGD:6496100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signal recognition particle binding activity. Predicted to be involved in several processes, including endoplasmic reticulum unfolded protein response; negative regulation of retrograde protein transport, ER to cytosol; and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within retrograde protein transport, ER to cytosol and suckling behavior. Predicted to be located in early endosome; endoplasmic reticulum; and late endosome. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human DERL2 (derlin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 241.4), Kidney (RPKM 95.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Derl2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (56226340..56238038, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55727764..55739442, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57641682..57653554, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene complement C1q binding protein Neighboring gene DEAH-box helicase 33 Neighboring gene MIS12 kinetochore complex component Neighboring gene chromobox protein homolog 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of F-LANa, upregulated in human liver cancer. Ying H, et al. Biochem Biophys Res Commun, 2001 Aug 17. PMID 11500051
    2. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Dougan SK, et al. Mol Cell Biol, 2011 Mar. PMID 21220515, Free PMC Article
    3. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. Oda Y, et al. J Cell Biol, 2006 Jan 30. PMID 16449189, Free PMC Article
    4. A membrane protein required for dislocation of misfolded proteins from the ER. Lilley BN, et al. Nature, 2004 Jun 24. PMID 15215855
    5. Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP. Kadowaki H, et al. Cell Rep, 2015 Nov 3. PMID 26565908

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signal recognition particle binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within suckling behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    derlin-2
    Names
    Der1-like domain family, member 2
    derlin-2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399430.1 → NP_001386359.1  derlin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HGB7
      Related
      ENSRNOP00000095156.1, ENSRNOT00000096117.1
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 203
      DER1; Der1-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      56226340..56238038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087317.2 → XP_038943245.1  derlin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMH0, A0A8I6GIB4, A6HGB5
      Related
      ENSRNOP00000090568.1
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 202
      DER1; Der1-like family

    2. XM_063268246.1 → XP_063124316.1  derlin-2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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