Stil STIL, centriolar assembly protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stilprovided by RGD
Official Full Name: STIL, centriolar assembly proteinprovided by RGD
Primary source: RGD:1304972
See related: Ensembl:ENSRNOG00000057760 AllianceGenome:RGD:1304972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sil
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to centrosome; and regulation of centriole replication. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic organ development; and non-motile cilium assembly. Predicted to be located in cytoplasm. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 7. Orthologous to human STIL (STIL centriolar assembly protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 67.6), Spleen (RPKM 49.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (133757598..133810493)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (128520837..128573732)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (133819302..133851362)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results provide direct evidence for the involvement of Stil in dopaminergic cell proliferation
Title: Characterization of the human oncogene SCL/TAL1 interrupting locus (Stil) mediated Sonic hedgehog (Shh) signaling transduction in proliferating mammalian dopaminergic neurons.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in centrosome duplication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within centrosome duplication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within floor plate development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart looping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within notochord development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of centriole replication	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of procentriole replication complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SCL-interrupting locus protein

Names: Scl/Tal1 interrupting locus; Tal1 interrupting locus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399206.1 → NP_001386135.1 SCL-interrupting locus protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2KB96

Related

ENSRNOP00000075706.2, ENSRNOT00000081075.2

Conserved Domains (1) summary

pfam15253
Location:22 → 426

STIL_N; SCL-interrupting locus protein N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

133757598..133810493

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287731.1 → XP_063143801.1 SCL-interrupting locus protein isoform X4
XM_039111180.2 → XP_038967108.1 SCL-interrupting locus protein isoform X1

UniProtKB/TrEMBL

A0A0G2KB96

Conserved Domains (1) summary

pfam15253
Location:22 → 426

STIL_N; SCL-interrupting locus protein N-terminus
XM_039111182.2 → XP_038967110.1 SCL-interrupting locus protein isoform X3

UniProtKB/TrEMBL

A0A0G2KB96

Conserved Domains (1) summary

pfam15253
Location:17 → 402

STIL_N; SCL-interrupting locus protein N-terminus
XM_039111181.2 → XP_038967109.1 SCL-interrupting locus protein isoform X2

UniProtKB/TrEMBL

A0A0G2KB96

Conserved Domains (1) summary

pfam15253
Location:13 → 417

STIL_N; SCL-interrupting locus protein N-terminus