Kif18a kinesin family member 18A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif18aprovided by RGD
Official Full Name: kinesin family member 18Aprovided by RGD
Primary source: RGD:1561740
See related: Ensembl:ENSRNOG00000005037 AllianceGenome:RGD:1561740
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561740
Summary: Predicted to enable several functions, including ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Involved in cellular response to estradiol stimulus. Predicted to be located in several cellular components, including caveola; kinetochore microtubule; and ruffle. Predicted to be part of kinesin complex. Predicted to be active in mitotic spindle astral microtubule; mitotic spindle midzone; and nucleus. Orthologous to human KIF18A (kinesin family member 18A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 99.4), Spleen (RPKM 64.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (116219007..116279378)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (95764388..95824756)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (100366168..100426867)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134079 (e-PCR)
- UniSTS:217361

RH132762 (e-PCR)
- UniSTS:216045

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables tubulin-dependent ATPase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within seminiferous tubule development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle astral microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF18A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001137642.1 → NP_001131114.1 kinesin-like protein KIF18A

See identical proteins and their annotated locations for NP_001131114.1

Status: PROVISIONAL

Source sequence(s)

CH473949

UniProtKB/TrEMBL

A6HNZ9, D3ZIA5

Related

ENSRNOP00000006689.5, ENSRNOT00000006689.7

Conserved Domains (2) summary

cl22853
Location:34 → 280

Motor_domain; Myosin and Kinesin motor domain

pfam00225
Location:34 → 280

Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

116219007..116279378

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105450.2 → XP_038961378.1 kinesin-like protein KIF18A isoform X1

UniProtKB/TrEMBL

A0A0G2JW74

Conserved Domains (1) summary

cd01370
Location:11 → 355

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
XM_017591908.3 → XP_017447397.2 kinesin-like protein KIF18A isoform X2

Conserved Domains (1) summary

cd01370
Location:11 → 355

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
XM_063284155.1 → XP_063140225.1 kinesin-like protein KIF18A isoform X3
XM_039105451.2 → XP_038961379.1 kinesin-like protein KIF18A isoform X1

UniProtKB/TrEMBL

A0A0G2JW74

Conserved Domains (1) summary

cd01370
Location:11 → 355

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
XM_039105452.2 → XP_038961380.1 kinesin-like protein KIF18A isoform X1

UniProtKB/TrEMBL

A0A0G2JW74

Related

ENSRNOP00000069771.2

Conserved Domains (1) summary

cd01370
Location:11 → 355

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup