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    Lrrc8c leucine rich repeat containing 8 family, member C [ Mus musculus (house mouse) ]

    Gene ID: 100604, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lrrc8cprovided by MGI
    Official Full Name
    leucine rich repeat containing 8 family, member Cprovided by MGI
    Primary source
    MGI:MGI:2140839
    See related
    Ensembl:ENSMUSG00000054720 AllianceGenome:MGI:2140839
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AD158; fad158; E430036I04Rik
    Summary
    Contributes to volume-sensitive anion channel activity. Involved in anion transmembrane transport and protein hexamerization. Acts upstream of or within fat cell differentiation. Located in endoplasmic reticulum. Is integral component of plasma membrane. Part of ion channel complex. Is expressed in retina. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 8.8), thymus adult (RPKM 7.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc8c in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105666850..105760884)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105519345..105613018)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6355 Neighboring gene predicted gene, 42141 Neighboring gene predicted gene, 42144 Neighboring gene STARR-seq mESC enhancer starr_13855 Neighboring gene STARR-positive B cell enhancer mm9_chr5:105986877-105987177 Neighboring gene STARR-seq mESC enhancer starr_13856 Neighboring gene STARR-seq mESC enhancer starr_13857 Neighboring gene STARR-positive B cell enhancer ABC_E11298 Neighboring gene STARR-positive B cell enhancer ABC_E3592 Neighboring gene STARR-positive B cell enhancer ABC_E4771 Neighboring gene STARR-positive B cell enhancer ABC_E4772 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:106077733-106078005 Neighboring gene STARR-positive B cell enhancer ABC_E11299 Neighboring gene predicted gene, 32230 Neighboring gene STARR-positive B cell enhancer ABC_E6356 Neighboring gene predicted gene, 32276

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet. Hayashi T, et al. Biol Pharm Bull, 2011. PMID 21804215
    2. Structure of a volume-regulated heteromeric LRRC8A/C channel. Rutz S, et al. Nat Struct Mol Biol, 2023 Jan. PMID 36522427, Free PMC Article
    3. Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. López-Cayuqueo KI, et al. J Am Soc Nephrol, 2022 Aug. PMID 35777784, Free PMC Article
    4. Structure of a volume-regulated anion channel of the LRRC8 family. Deneka D, et al. Nature, 2018 Jun. PMID 29769723
    5. The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation. Tominaga K, et al. J Biol Chem, 2004 Aug 13. PMID 15184384

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of a volume-regulated heteromeric LRRC8A/C channel.
      Title: Structure of a volume-regulated heteromeric LRRC8A/C channel.
    2. These results indicate that fad158 is a key factor in the development of obesity and insulin resistance caused by a high-fat diet.
      Title: Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet.
    3. fad158 has a role in regulating adipocyte differentiation
      Title: The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to volume-sensitive anion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic anion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein hexamerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in taurine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of monoatomic ion channel complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of monoatomic ion channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    volume-regulated anion channel subunit LRRC8C
    Names
    factor for adipocyte differentiation 158
    leucine-rich repeat-containing protein 8C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133897.2 → NP_598658.1  volume-regulated anion channel subunit LRRC8C

      See identical proteins and their annotated locations for NP_598658.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122566, AC138265
      Consensus CDS
      CCDS19493.1
      UniProtKB/Swiss-Prot
      Q3TEP9, Q8C296, Q8R0N7, Q8R3G5, Q8R502
      Related
      ENSMUSP00000066015.7, ENSMUST00000067924.13
      Conserved Domains (3) summary
      COG4886
      Location:528 → 775
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:591 → 613
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 338
      Pannexin_like; Pannexin-like TM region of LRRC8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      105666850..105760884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534685.4 → XP_006534748.1  volume-regulated anion channel subunit LRRC8C isoform X1

      See identical proteins and their annotated locations for XP_006534748.1

      UniProtKB/Swiss-Prot
      Q3TEP9, Q8C296, Q8R0N7, Q8R3G5, Q8R502
      Conserved Domains (3) summary
      COG4886
      Location:528 → 775
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:591 → 613
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 338
      Pannexin_like; Pannexin-like TM region of LRRC8

    2. XM_017320573.2 → XP_017176062.1  volume-regulated anion channel subunit LRRC8C isoform X1

      UniProtKB/Swiss-Prot
      Q3TEP9, Q8C296, Q8R0N7, Q8R3G5, Q8R502
      Conserved Domains (3) summary
      COG4886
      Location:528 → 775
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:591 → 613
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 338
      Pannexin_like; Pannexin-like TM region of LRRC8

    3. XM_006534686.5 → XP_006534749.1  volume-regulated anion channel subunit LRRC8C isoform X2

      Conserved Domains (3) summary
      COG4886
      Location:481 → 728
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:544 → 566
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 291
      Pannexin_like; Pannexin-like TM region of LRRC8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R502.1 GenPept UniProtKB/Swiss-Prot:Q8R502

    Gene LinkOut

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