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Wnt5a wingless-type MMTV integration site family, member 5A [ Mus musculus (house mouse) ]

Gene ID: 22418, updated on 21-Apr-2024

Summary

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Official Symbol: Wnt5aprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 5Aprovided by MGI
Primary source: MGI:MGI:98958
See related: Ensembl:ENSMUSG00000021994 AllianceGenome:MGI:98958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wnt-5a; 8030457G12Rik
Summary: Enables frizzled binding activity; protein domain specific binding activity; and receptor ligand activity. Involved in several processes, including Wnt signaling pathway; heart development; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; positive regulation of protein phosphorylation; and regulation of animal organ morphogenesis. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; limb; and sensory organ. Used to study Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 24.5), bladder adult (RPKM 18.8) and 17 other tissues See more
Orthologs: human all
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Genomic context

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Location:: 14 A3; 14 16.8 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (28224962..28249405)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (28504543..28527448)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt5a/Ror2 promotes Nrf2-mediated tissue protective function of astrocytes after brain injury.
Title: Wnt5a/Ror2 promotes Nrf2-mediated tissue protective function of astrocytes after brain injury.
CCNK Gene Deficiency Influences Neural Progenitor Cells Via Wnt5a Signaling in CCNK-Related Syndrome.
Title: CCNK Gene Deficiency Influences Neural Progenitor Cells Via Wnt5a Signaling in CCNK-Related Syndrome.
Hedgehog signalling in Foxd1+ embryonic kidney stromal progenitors controls nephron formation via Cxcl12 and Wnt5a.
Title: Hedgehog signalling in Foxd1+ embryonic kidney stromal progenitors controls nephron formation via Cxcl12 and Wnt5a.
The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.
Title: The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.
FOXF1 Regulates Alveolar Epithelial Morphogenesis through Transcriptional Activation of Mesenchymal WNT5A.
Title: FOXF1 Regulates Alveolar Epithelial Morphogenesis through Transcriptional Activation of Mesenchymal WNT5A.
Wnt5a regulates autophagy in Bacille Calmette-Guerin (BCG)-Infected pulmonary epithelial cells.
Title: Wnt5a regulates autophagy in Bacille Calmette-Guérin (BCG)-Infected pulmonary epithelial cells.
WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer.
Title: WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer.
Wnt5a Promotes AT1 and Represses AT2 Lineage-Specific Gene Expression in a Cell-Context-Dependent Manner.
Title: Wnt5a Promotes AT1 and Represses AT2 Lineage-Specific Gene Expression in a Cell-Context-Dependent Manner.
YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity.
Title: YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity.
The mechanism of the WNT5A and FZD4 receptor mediated WNT/beta-catenin pathway in the degeneration of ALS spinal cord motor neurons.
Title: The mechanism of the WNT5A and FZD4 receptor mediated WNT/β-catenin pathway in the degeneration of ALS spinal cord motor neurons.

Submit: New GeneRIF Correction See all GeneRIFs (242)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt5a (e-PCR), detects polymorphism
- UniSTS:508417

Wnt5a (e-PCR), detects polymorphism
- UniSTS:508418

Wnt5a (e-PCR), detects polymorphism
- UniSTS:465422

Wnt5a (e-PCR), detects polymorphism
- UniSTS:471326

Wnt5a (e-PCR), detects polymorphism
- UniSTS:527140

Wnt5a (e-PCR), detects polymorphism
- UniSTS:265272

Wnt5a (e-PCR), detects polymorphism
- UniSTS:464699

MDB0332 (e-PCR)
- UniSTS:125016

NoName (e-PCR)
- UniSTS:237146

Wnt5a (e-PCR), detects polymorphism
- UniSTS:526950

Wnt5a (e-PCR), detects polymorphism
- UniSTS:277885

Wnt5a (e-PCR), detects polymorphism
- UniSTS:508547

BB055853 (e-PCR)
- UniSTS:185993

Wnt5a (e-PCR), detects polymorphism
- UniSTS:144779

Wnt5a (e-PCR), detects polymorphism
- UniSTS:144780

Wnt5a (e-PCR), detects polymorphism
- UniSTS:144781

Wnt5a (e-PCR), detects polymorphism
- UniSTS:466088

Wnt5a (e-PCR), detects polymorphism
- UniSTS:546472

Wnt5a (e-PCR), detects polymorphism
- UniSTS:499118

Wnt5a (e-PCR), detects polymorphism
- UniSTS:526002

Wnt5a (e-PCR), detects polymorphism
- UniSTS:507320

Wnt5a (e-PCR), detects polymorphism
- UniSTS:498361

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IDA Inferred from Direct Assay more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase-like orphan receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway, calcium modulating pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, calcium modulating pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway, calcium modulating pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway, planar cell polarity pathway	TAS Traceable Author Statement more info	PubMed
involved_in activation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in anterior/posterior axis specification, embryo	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial septum development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axonal fasciculation	TAS Traceable Author Statement more info	PubMed
involved_in axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cervix development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemoattraction of serotonergic neuron axon	IDA Inferred from Direct Assay more info	PubMed
involved_in chemorepulsion of dopaminergic neuron axon	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in organogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within development of primary male sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopaminergic neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in face development	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genitalia development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart looping	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypophysis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral sprouting involved in mammary gland duct morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland branching involved in thelarche	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of meiotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in melanocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal-epithelial cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesodermal to mesenchymal transition involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in midbrain development	IDA Inferred from Direct Assay more info	PubMed
involved_in midbrain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in midbrain dopaminergic neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in midbrain dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in midbrain dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell proliferation in midbrain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of melanin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of prostatic bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in non-canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in olfactory bulb interneuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within paraxial mesoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pericardium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in cardiac right atrium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in gastrula mediolateral intercalation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in pericardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cartilage development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by cadherin	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of meiotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection arborization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron projection arborization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of non-canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-threonine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of thymocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of timing of anagen	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary heart field specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within primitive streak formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic specialization assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic signaling by nitric oxide	ISO Inferred from Sequence Orthology more info
involved_in secondary heart field specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within somite development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of thymocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type B pancreatic cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within urinary bladder development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vagina development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Wnt-5a

Names: wingless-related MMTV integration site 5A

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256224.2 → NP_001243153.1 protein Wnt-5a isoform 2 precursor

See identical proteins and their annotated locations for NP_001243153.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK036824, CT025649

Consensus CDS

CCDS56946.1

UniProtKB/Swiss-Prot

P22725

Related

ENSMUSP00000107891.2, ENSMUST00000112272.2

Conserved Domains (1) summary

cd19347
Location:49 → 360

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
NM_009524.4 → NP_033550.2 protein Wnt-5a isoform 1 precursor

See identical proteins and their annotated locations for NP_033550.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK031512, AK031597, AK036824, BY721304, CT025649

Consensus CDS

CCDS26888.1

UniProtKB/Swiss-Prot

P22725, Q8BM17, Q8BMF9, Q8VCV6

Related

ENSMUSP00000064878.5, ENSMUST00000063465.12

Conserved Domains (1) summary

cd19347
Location:69 → 380

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

28224962..28249405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247779.2 → XP_030103639.1 protein Wnt-5a isoform X2

Conserved Domains (1) summary

cd19347
Location:49 → 360

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
XM_006518924.4 → XP_006518987.1 protein Wnt-5a isoform X2

See identical proteins and their annotated locations for XP_006518987.1

UniProtKB/Swiss-Prot

P22725

Conserved Domains (1) summary

cd19347
Location:49 → 360

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
XM_006518923.4 → XP_006518986.1 protein Wnt-5a isoform X1

Conserved Domains (1) summary

cd19347
Location:82 → 393

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins