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    Tcf19 transcription factor 19 [ Mus musculus (house mouse) ]

    Gene ID: 106795, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tcf19provided by MGI
    Official Full Name
    transcription factor 19provided by MGI
    Primary source
    MGI:MGI:103180
    See related
    Ensembl:ENSMUSG00000050410 AllianceGenome:MGI:103180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730403J10Rik
    Summary
    Acts upstream of or within G1/S transition of mitotic cell cycle; regulation of gene expression; and type B pancreatic cell proliferation. Located in nucleus. Is expressed in forebrain; genitourinary system; and limb. Orthologous to human TCF19 (transcription factor 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 21.9), thymus adult (RPKM 20.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 18.69 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35823627..35827730, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35512730..35516837, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene Pou5f1 5' regulatory region Neighboring gene predicted gene, 32362 Neighboring gene POU domain, class 5, transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_42459 Neighboring gene STARR-positive B cell enhancer mm9_chr17:35653747-35654048 Neighboring gene coiled-coil alpha-helical rod protein 1 Neighboring gene psoriasis susceptibility 1 candidate 2 (human)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse. Kanki JP, et al. J Neurobiol, 1994 Jul. PMID 8089660
    2. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. Ku DH, et al. Cell Growth Differ, 1991 Apr. PMID 1868030
    3. Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line. Krautkramer KA, et al. Am J Physiol Endocrinol Metab, 2013 Sep 1. PMID 23860123, Free PMC Article
    4. Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding. Bowen MA, et al. Eur J Immunol, 1997 Jun. PMID 9209500
    5. Individual retinal progenitor cells display extensive heterogeneity of gene expression. Trimarchi JM, et al. PLoS One, 2008 Feb 13. PMID 18270576, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within type B pancreatic cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor 19-like protein
    Names
    SC1 protein homolog
    TCF-19

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163763.1 → NP_001157235.1  transcription factor 19-like protein

      See identical proteins and their annotated locations for NP_001157235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK004231, AK077414, AK078697, BB873636, BG082313
      Consensus CDS
      CCDS50089.1
      UniProtKB/Swiss-Prot
      Q8BPA3, Q99KJ5, Q9CT93
      UniProtKB/TrEMBL
      G3XA31
      Related
      ENSMUSP00000125167.2, ENSMUST00000160885.2
      Conserved Domains (2) summary
      cd00060
      Location:5 → 123
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR03354
      Location:36 → 240
      VI_FHA; type VI secretion system FHA domain protein

    2. NM_001163764.1 → NP_001157236.1  transcription factor 19-like protein

      See identical proteins and their annotated locations for NP_001157236.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK004231, AK077414, BB873636, BG082313, CX220762
      Consensus CDS
      CCDS50089.1
      UniProtKB/Swiss-Prot
      Q8BPA3, Q99KJ5, Q9CT93
      UniProtKB/TrEMBL
      G3XA31
      Conserved Domains (2) summary
      cd00060
      Location:5 → 123
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR03354
      Location:36 → 240
      VI_FHA; type VI secretion system FHA domain protein

    3. NM_025674.2 → NP_079950.2  transcription factor 19-like protein

      See identical proteins and their annotated locations for NP_079950.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK004231, AK077414, BB873636, BG082313
      Consensus CDS
      CCDS50089.1
      UniProtKB/Swiss-Prot
      Q8BPA3, Q99KJ5, Q9CT93
      UniProtKB/TrEMBL
      G3XA31
      Related
      ENSMUSP00000125310.2, ENSMUST00000161012.8
      Conserved Domains (2) summary
      cd00060
      Location:5 → 123
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR03354
      Location:36 → 240
      VI_FHA; type VI secretion system FHA domain protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35823627..35827730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249438.2 → XP_030105298.1  transcription factor 19-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q8BPA3, Q99KJ5, Q9CT93
      UniProtKB/TrEMBL
      G3XA31
      Conserved Domains (2) summary
      cd00060
      Location:5 → 123
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR03354
      Location:36 → 240
      VI_FHA; type VI secretion system FHA domain protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KJ5.1 GenPept UniProtKB/Swiss-Prot:Q99KJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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