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    Ap3m1 adaptor related protein complex 3 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171126, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Ap3m1provided by RGD
    Official Full Name
    adaptor related protein complex 3 subunit mu 1provided by RGD
    Primary source
    RGD:620417
    See related
    Ensembl:ENSRNOG00000011461 AllianceGenome:RGD:620417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P47a
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in anterograde synaptic vesicle transport and endocytosis. Predicted to be located in Golgi apparatus; axon cytoplasm; and cytoplasmic vesicle membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in cytoplasmic vesicle. Orthologous to human AP3M1 (adaptor related protein complex 3 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 158.5), Lung (RPKM 156.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3285591..3314139)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3246616..3264846)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (3435998..3454281)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene adenosine kinase Neighboring gene uncharacterized LOC120097065 Neighboring gene uncharacterized LOC120097066 Neighboring gene vinculin Neighboring gene uncharacterized LOC120096900 Neighboring gene plasminogen activator, urokinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex. Mardones GA, et al. J Biol Chem, 2013 Mar 29. PMID 23404500, Free PMC Article
    2. Direct interaction of Dysbindin with the AP-3 complex via its mu subunit. Taneichi-Kuroda S, et al. Neurochem Int, 2009 Jun. PMID 19428785
    3. Two rat homologs of clathrin-associated adaptor proteins. Pevsner J, et al. Gene, 1994 Sep 2. PMID 8076832
    4. BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles. Bultema JJ, et al. J Biol Chem, 2012 Jun 1. PMID 22511774, Free PMC Article
    5. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for the recognition of tyrosine-based sorting signals by the mu3A subunit of the AP-3 adaptor complex
      Title: Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterograde axonal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in anterograde synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterograde synaptic vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-3 complex subunit mu-1
    Names
    AP-3 adapter complex mu3A subunit
    AP-3 adaptor complex mu3A subunit
    HA1 47 kDa subunit homolog 1
    Mu-adaptin 3A
    adapter-related protein complex 3 mu-1 subunit
    adapter-related protein complex 3 subunit mu-1
    adaptor-related protein complex 3, mu 1 subunit
    adaptor-related protein complex AP-3, mu 1 subunit
    clathrin assembly protein assembly protein complex 1 medium chain homolog 1
    clathrin assembly protein assembly protein complex 3 mu-1 medium chain
    clathrin coat assembly protein AP47 homolog 1
    clathrin coat-associated protein AP47 homolog 1
    clathrin-associated adaptor protein homolog (p47A)
    golgi adaptor AP-1 47 kDa protein homolog 1
    mu3A-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133593.2 → NP_598277.2  AP-3 complex subunit mu-1

      See identical proteins and their annotated locations for NP_598277.2

      Status: PROVISIONAL

      Source sequence(s)
      BC070925
      UniProtKB/Swiss-Prot
      P53676
      UniProtKB/TrEMBL
      A6KKR5, F7FH36, Q6IRG9
      Related
      ENSRNOP00000016387.3, ENSRNOT00000016387.5
      Conserved Domains (2) summary
      cd09260
      Location:165 → 418
      AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      3285591..3314139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251630.5 → XP_006251692.2  AP-3 complex subunit mu-1 isoform X1

    2. XM_006251629.4 → XP_006251691.1  AP-3 complex subunit mu-1 isoform X2

      See identical proteins and their annotated locations for XP_006251691.1

      UniProtKB/Swiss-Prot
      P53676
      UniProtKB/TrEMBL
      A6KKR5, F7FH36, Q6IRG9
      Related
      ENSRNOP00000093883.1
      Conserved Domains (2) summary
      cd09260
      Location:165 → 418
      AP-3_Mu3A_Cterm; C-terminal domain of medium Mu3A subunit in ubiquitously expressed adaptor protein (AP) complex AP-3
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53676.1 GenPept UniProtKB/Swiss-Prot:P53676

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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