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    St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64442, updated on 29-Mar-2024

    Summary

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    Official Symbol
    St3gal2provided by RGD
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 2provided by RGD
    Primary source
    RGD:68413
    See related
    Ensembl:ENSRNOG00000017932 AllianceGenome:RGD:68413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat5; Siat4b
    Summary
    Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide and protein glycosylation. Predicted to be located in Golgi membrane. Orthologous to human ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 149.0), Muscle (RPKM 140.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    19q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55798112..55849226)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38888851..38939874)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43273251..43324265, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 4 Neighboring gene fucose kinase Neighboring gene uncharacterized LOC134483368 Neighboring gene DEAD-box helicase 19A Neighboring gene DEAD-box helicase 19B Neighboring gene alanyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides. Chandrasekaran EV, et al. Biochemistry, 2011 Nov 8. PMID 21913655, Free PMC Article
    2. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. Giordanengo V, et al. Eur J Biochem, 1997 Jul 15. PMID 9266697
    3. Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase. Lee YC, et al. J Biol Chem, 1994 Apr 1. PMID 8144500
    4. Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Kono M, et al. Glycobiology, 1997 Jun. PMID 9184827
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Use of sialyl mucin core 2 compounds shows how ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcalpha2,3Galbeta1,3GalNAc unit, while also radiolabeling sialyl residues in gangliosides GD1a and GT1b, but not GM1.
      Title: Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process via lactosylceramide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process via lactosylceramide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in globoside biosynthetic process via lactosylceramide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in globoside biosynthetic process via lactosylceramide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in globoside biosynthetic process via lactosylceramide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sialylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
    Names
    SIAT4-B
    ST3GALA.2
    ST3Gal II
    ST3GalII
    alpha 2,3-ST 2
    beta-galactoside alpha-2,3-sialyltransferase 2
    gal-NAc6S
    gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    monosialoganglioside sialyltransferase
    sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase)
    sialyltransferase 5
    NP_113883.2
    XP_006255687.1
    XP_006255688.1
    XP_006255689.1
    XP_038953889.1
    XP_038953890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031695.2 → NP_113883.2  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

      See identical proteins and their annotated locations for NP_113883.2

      Status: VALIDATED

      Source sequence(s)
      CO404237, EV769154, JAXUCZ010000019, X76988
      UniProtKB/Swiss-Prot
      Q11205
      UniProtKB/TrEMBL
      A6IZ75, G3V8B2
      Related
      ENSRNOP00000024248.2, ENSRNOT00000024248.4
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55798112..55849226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097961.2 → XP_038953889.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q11205
      UniProtKB/TrEMBL
      A6IZ75, G3V8B2
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006255627.5 → XP_006255689.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006255689.1

      UniProtKB/Swiss-Prot
      Q11205
      UniProtKB/TrEMBL
      A6IZ75, G3V8B2
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_006255625.5 → XP_006255687.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006255687.1

      UniProtKB/Swiss-Prot
      Q11205
      UniProtKB/TrEMBL
      A6IZ75, G3V8B2
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_006255626.5 → XP_006255688.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006255688.1

      UniProtKB/Swiss-Prot
      Q11205
      UniProtKB/TrEMBL
      A6IZ75, G3V8B2
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_039097962.2 → XP_038953890.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:11 → 237
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11205.1 GenPept UniProtKB/Swiss-Prot:Q11205

    Gene LinkOut

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