Gtf2b general transcription factor IIB [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gtf2bprovided by RGD
Official Full Name: general transcription factor IIBprovided by RGD
Primary source: RGD:619735
See related: Ensembl:ENSRNOG00000011135 AllianceGenome:RGD:619735
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; RNA polymerase II general transcription initiation factor activity; and TBP-class protein binding activity. Predicted to be involved in several processes, including RNA polymerase II core complex assembly; positive regulation of core promoter binding activity; and transcription initiation from RNA polymerase II promoter. Predicted to be located in chromosome and nuclear body. Predicted to be part of transcription factor TFIID complex and transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human GTF2B (general transcription factor IIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 287.7), Thymus (RPKM 226.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (234427734..234446043)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (231767317..231785626)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (248709433..248727741)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TFIIB was expressed in normal sciatic nerve. It gradually increased, reached a peak at the 7th day after crush, and then returned to the normal level at 4 weeks. Its expression mainly increased in Schwann cells.
Title: Transcription initiation factor IIB involves in Schwann cell differentiation after rat sciatic nerve crush.
Spatiotemporal changes of TFIIB expression suggest that this protein may play a role in the degenerative process of RGCs by light-induced damage in the retina.
Title: Involvement of transcription initiation factor IIB in the light-induced death of rat retinal ganglion cells in vivo.
Findings show that TFIIB binding is not restricted to the 5' upstream region indicates that the propensity for pre-initiation complex to contribute to transcript diversity is far greater than previously appreciated.
Title: Localization of TFIIB binding regions using serial analysis of chromatin occupancy.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF389714 (e-PCR)
- UniSTS:245521

RH136605 (e-PCR)
- UniSTS:210585

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II complex binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II complex binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II core promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nuclear thyroid hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II core complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II core complex assembly	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II core complex assembly	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II core complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in meiotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in meiotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in transcriptional start site selection at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcriptional start site selection at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcriptional start site selection at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
involved_in transcriptional start site selection at RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
involved_in viral transcription	IEA Inferred from Electronic Annotation more info
involved_in viral transcription	ISO Inferred from Sequence Orthology more info
involved_in viral transcription	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cell division site	IEA Inferred from Electronic Annotation more info
is_active_in cell division site	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in germinal vesicle	IEA Inferred from Electronic Annotation more info
is_active_in germinal vesicle	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFIID complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info
part_of transcription preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription initiation factor IIB

Names: RNA polymerase II alpha initiation factor; general transcription factor TFIIB

NP_112303.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031041.2 → NP_112303.1 transcription initiation factor IIB

See identical proteins and their annotated locations for NP_112303.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P29053, P62916

UniProtKB/TrEMBL

A0A0A0MXW7, A6HW74

Related

ENSRNOP00000070077.2, ENSRNOT00000089648.2

Conserved Domains (1) summary

COG1405
Location:14 → 290

SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]